Results 101 to 110 of about 92,514 (295)

Effect of mass-loss due to stellar winds on the formation of supermassive black hole seeds in dense nuclear star clusters [PDF]

, 2021
Arpan Das, D. R. G. Schleicher, Shantanu Basu, Tjarda Boekholt   +3 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Proton Acceleration in Colliding Stellar Wind Binaries [PDF]

, 2019
Emanuele Grimaldo, Anita Reimer, Ralf Kissmann, Felix Niederwanger, Klaus Reitberger   +4 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Stellar Wind Parameters of Massive Stars in Accretion-Powered High-Mass X-Ray Binary Pulsars

Galaxies
The process of mass exchange between the components of High-Mass X-ray Binary (HMXB) systems with neutron stars undergoing wind-fed accretion is discussed.
Nina Beskrovnaya, Nazar Ikhsanov, Vitaliy Kim   +2 more
doaj   +1 more source

Simulating the Interaction of a Non-magnetized Planet with the Stellar Wind Produced by a Sun-like Star Using the FLASH Code [PDF]

, 2019
Edgard F. D. Evangelista, Oswaldo D. Miranda, Odim Mendes, Margarete O. Domingues   +3 more
openalex   +1 more source

Interaction of the Exoplanet Hat–P–11b with Stellar Wind [PDF]

, 2023
E. S. Belenkaya
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Detection of Diffuse Hot Gas around the Young, Potential Superstar Cluster H72.97–69.39

The Astrophysical Journal
We present the first Chandra X-ray observations of H72.97–69.39, a highly embedded, potential superstar cluster in its infancy located in the star-forming complex N79 of the Large Magellanic Cloud. We detect particularly hard, diffuse X-ray emission that
Trinity L. Webb, Jennifer A. Rodriguez, Laura A. Lopez, Anna L. Rosen, Lachlan Lancaster, Omnarayani Nayak, Anna F. McLeod, Paarmita Pandey, Grace M. Olivier   +8 more
doaj   +1 more source

The Efficiency of Mass Accretion and Disc Structure from the Stellar Wind Mass Transfer in Binary Systems

Universe
There have been many research works involving mass transfer in stellar binaries, all of which are limited to certain systems with specific binary parameters.
Bushra Ata Ali, Hastyar Omar Mohammed, Peshwaz Abdulkareem Abdoul   +2 more
doaj   +1 more source