ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Simulations of stellar/pulsar-wind interaction along one full orbit [PDF]
, 2012 V. Bosch-Ramon +3 more
openalex +1 more source
Lyman alpha initiated winds in late-type stars [PDF]
The IUE survey of late-type stars revealed a sharp division in the HR diagram between stars with solar type spectra (chromosphere and transition region lines) and those with non-solar type spectra (only chromosphere lines). Models of both hot coronae and
Haisch, B. M. +2 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Weakened Magnetic Braking in the Exoplanet Host Star 51 Peg
The Astrophysical Journal LettersThe consistently low activity level of the old solar analog 51 Peg not only facilitated the discovery of the first hot Jupiter, but also led to the suggestion that the star could be experiencing a magnetic grand minimum.
Travis S. Metcalfe +13 more
doaj +1 more source
The galactic mass injection from cool stellar winds of the 1 to 2.5 ${\vec M}_{\odot}$ stars in the solar neighbourhood [PDF]
, 2001 K.‐P. Schröder, E. Sedlmayr
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Stellar-wind-blown Bubbles as Environments for Late-time Rebrightening of Gamma-ray Burst Afterglows
The Astrophysical Journal LettersWe present multiwavelength afterglow fitting results for three events that exhibit late afterglow rebrightening behavior: EP240414a ( z = 0.401), GRB 240529A ( z = 2.695), and GRB 240218A ( z = 6.782), which span a broad range of redshifts, from the ...
Jia Ren +7 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
GLOBAL SIMULATIONS OF THE INTERACTION OF MICROQUASAR JETS WITH A STELLAR WIND IN HIGH-MASS X-RAY BINARIES [PDF]
, 2015 Doosoo Yoon, Sebastian Heinz
openalex +1 more source