Results 151 to 160 of about 91,502 (296)

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

Constraining the Diffusion Coefficient and Cosmic-Ray Acceleration Efficiency Using Gamma-Ray Emission from the Star-forming Region RCW 38

The Astrophysical Journal
Stellar winds from massive stars may be significant sources of cosmic rays (CRs). To investigate this connection, we report a detailed study of gamma-ray emission near the young Milky Way star cluster (≈0.5 Myr old) in the star-forming region RCW 38 and ...
Paarmita Pandey, Laura A. Lopez, Anna L. Rosen, Todd A. Thompson, Tim Linden, Ian Blackstone   +5 more
doaj   +1 more source

Stellar winds in high-mass X-ray binaries [PDF]

, 1995
L. Kaper
openalex   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Geometric Correction for Wind Accretion in Binary Systems

The Astrophysical Journal
The Bondi–Hoyle–Lyttleton (BHL) accretion model is widely used to describe how a compact object accretes material from a companion's stellar wind in binary systems.
Emilio Tejeda, Jesús A. Toalá
doaj   +1 more source

Simulations of stellar/pulsar-wind interaction along one full orbit [PDF]

, 2012
V. Bosch-Ramon, M. V. Barkov, D. Khangulyan, M. Perucho   +3 more
openalex   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Measurements of Low Temperature Rate Coefficients for the Reaction of CH with CH₂O and Application to Dark Cloud and AGB Stellar Wind Models [PDF]

, 2019
Niclas A. West, Tom J. Millar, Marie Van de Sande, Edward Rutter, Mark A. Blitz, Leen Decin, Dwayne E. Heard, Niclas A. West, Tom J. Millar, Marie Van de Sande, Edward Rutter, Mark A. Blitz, Leen Decin, Dwayne E. Heard   +13 more
openalex   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source