Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski +13 more
wiley +1 more source
Repeating fast radio burst 20201124A originates from a magnetar/Be star binary. [PDF]
Wang FY, Zhang GQ, Dai ZG, Cheng KS.
europepmc +1 more source
Genetic Modifiers of Parkinson's Disease: A Case–Control Study
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik +15 more
wiley +1 more source
Global heliospheric termination shock strength in the solar-interstellar interaction. [PDF]
Zirnstein EJ +6 more
europepmc +1 more source
Cosmic ray feedback in galaxies and galaxy clusters: A pedagogical introduction and a topical review of the acceleration, transport, observables, and dynamical impact of cosmic rays. [PDF]
Ruszkowski M, Pfrommer C.
europepmc +1 more source
Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo +13 more
wiley +1 more source
Extreme weather variability on hot rocky exoplanet 55 Cancri e explained by magma temperature-cloud feedback. [PDF]
Loftus K, Luo Y, Fan B, Kite ES.
europepmc +1 more source
Accretion-powered Stellar Winds as a Solution to the Stellar Angular Momentum Problem [PDF]
Sean P. Matt, Ralph E. Pudritz
openalex +1 more source
Assessing a Mitochondrial Disease Treatment via a Novel Statistical Technique for Accelerometer Data
ABSTRACT Objective Therapeutic development for mitochondrial diseases, rare genetic disorders with pathogenic defects of oxidative phosphorylation, is hindered by unsatisfactory outcome measures. To address this problem, we provide the first clinical application of a novel, bias‐adjusted outcome measure of acceleration across a range of subjects ...
Ian W. McKeague +8 more
wiley +1 more source

