Results 41 to 50 of about 91,502 (296)

Astrospheres and Solar-like Stellar Winds

Living Reviews in Solar Physics, 2004
Stellar analogs for the solar wind have proven to be frustratingly difficult to detect directly. However, these stellar winds can be studied indirectly by observing the interaction regions carved out by the collisions between these winds and the ...
Wood Brian E.
doaj  

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

The Important Role of Cosmic-Ray Re-Acceleration

Galaxies, 2019
In the last decades, the improvement of high energy instruments has enabled a deeper understanding of the Cosmic Ray origin issue. In particular, the γ -ray satellites AGILE (Astrorivelatore Gamma ad Immagini LEggero) and Fermi-LAT (Fermi-Large
Martina Cardillo
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Critical Metallicity of Cool Supergiant Formation. I. Effects on Stellar-mass Loss and Feedback

The Astrophysical Journal, 2023
This paper systematically studies the relation between metallicity and mass loss of massive stars. We perform one-dimensional stellar evolution simulations and build a grid of ∼2000 models with initial masses ranging between 11 and 60 M _⊙ and absolute ...
Po-Sheng Ou, Ke-Jung Chen, You-Hua Chu, Sung-Han Tsai   +3 more
doaj   +1 more source

X-Ray Wind Tomography of the highly absorbed HMXB IGR J17252-3616

, 2010
Our goal is to understand the specificities of highly absorbed sgHMXB and in particular of the companion stellar wind, thought to be responsible for the strong absorption.
A. Manousakis, Blondin, Blondin, Blondin, Blondin, Castor, Chaty, Choi, Corbet, Day, Dickey, Endo, Fransson, Fürst, Güdel, Haberl, Hickox, Jansen, Joss, Kallman, Kallman, Lebrun, Levine, Liu, Mason, Mason, Matt, Ohashi, Press, Quaintrell, R. Walter, Rahoui, Schulz, Strüder, Takeuchi, Tawara, Thompson, van Kerkwijk, Walter, Walter, Warwick, Watanabe, White, Winkler, Zurita Heras   +44 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Interactions between exoplanets and the winds of young stars

EPJ Web of Conferences, 2014
The topology of the magnetic field of young stars is important not only for the investigation of magnetospheric accretion, but also responsible in shaping the large-scale structure of stellar winds, which are crucial for regulating the rotation evolution
Vidotto A. A., Opher M., Jatenco-Pereira V., Gombosi T. I.   +3 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source