Results 61 to 70 of about 91,502 (296)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Rotational Evolution of Classical T Tauri Stars: Models and Observations

The Astrophysical Journal
We developed a grid of stellar rotation models for low-mass and solar-type classical T Tauri stars (CTTS; 0.3 M _⊙ < M _* < 1.2 M _⊙ ). These models incorporate the star–disk interaction and magnetospheric ejections to investigate the evolution of the ...
Javier Serna, Giovanni Pinzón, Jesús Hernández, Ezequiel Manzo-Martínez, Karina Mauco, Carlos G. Román-Zúñiga, Nuria Calvet, Cesar Briceño, Ricardo López-Valdivia, Marina Kounkel, Guy S. Stringfellow, Keivan G. Stassun, Marc Pinsonneault, Lucia Adame, Lyra Cao, Kevin Covey, Amelia Bayo, Alexandre Roman-Lopes, Christian Nitschelm, Richard R. Lane   +19 more
doaj   +1 more source

The Effects of Stellar Wind, Rotation Velocity, and Overshoot Parameters on The Evolution of Massive Stars using MESA: Case Study of MPG 324, MPG 355, MPG 682

Spektra: Jurnal Fisika dan Aplikasinya
Massive stars (over 8 solar masses) undergo intricate cosmic journeys. Their evolution, shaped by parameters like stellar wind, rotation velocity, and overshoot, generally includes the pre-main sequence, main sequence, and post-main sequence phases.
Alin Hafizhah Adira, Aprilia
doaj   +1 more source

3-D radiative transfer in clumped hot star winds I. Influence of clumping on the resonance line formation

, 2012
The true mass-loss rates from massive stars are important for many branches of astrophysics. For the correct modeling of the resonance lines, which are among the key diagnostics of stellar mass-loss, the stellar wind clumping turned out to be very ...
A. Feldmeier, Avery, B. Šurlan, Bouret, Bouret, Box, Caroff, Castor, Cranmer, Dessart, Dessart, Eversberg, Feldmeier, Feldmeier, Feldmeier, Feldmeier, Fullerton, Hamann, Hamann, Hamann, Hamann, Hamann, Hillier, J. Kubát, Korčáková, Korčáková, Krtička, Krtička, L. M. Oskinova, Lobel, Lucy, Lucy, Lucy, Lépine, Lépine, Maeder, Markova, Muijres, Mullan, Oskinova, Oskinova, Oskinova, Owocki, Owocki, Owocki, Pauldrach, Prinja, Prinja, Prinja, Puls, Puls, Runacres, Sundqvist, Sundqvist, W.-R. Hamann, Waldron, Whitney, Zsargó   +57 more
core   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Wind Roche-lobe Overflow in Low-mass Binaries: Exploring the Origin of Rapidly Rotating Blue Lurkers

The Astrophysical Journal
Wind Roche-lobe overflow (WRLOF) is a mass-transfer mechanism proposed by Mohamed and Podsiadlowski for stellar binaries wherein the wind acceleration zone of the donor star exceeds its Roche-lobe radius, allowing stellar wind material to be transferred ...
Meng Sun, Sasha Levina, Seth Gossage, Vicky Kalogera, Emily M. Leiner, Aaron M. Geller, Zoheyr Doctor   +6 more
doaj   +1 more source

Properties of interstellar wind leading to shape morphology of the dust surrounding HD 61005

, 2017
A structure formed by dust particles ejected from the debris ring around HD 61005 is observed in the scattered light. The main aim here is to constrain interstellar wind parameters that lead to shape morphology in the vicinity of HD 61005 using currently
Pastor, P.
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Spin-down of Solar-mass Protostars in Magnetospheric Accretion Paradigm

The Astrophysical Journal
Stellar spin is one of the fundamental quantities that characterize a star itself and its planetary system. Nevertheless, stellar spin-down mechanisms in protostellar and pre-main-sequence stellar phases have been a long-standing problem in star ...
Shinsuke Takasao, Masanobu Kunitomo, Takeru K. Suzuki, Kazunari Iwasaki, Kengo Tomida   +4 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source