Results 71 to 80 of about 92,514 (295)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The applicability of the wind compression model

, 2014
Compression of the stellar winds from rapidly rotating hot stars is described by the wind compression model. However, it was also shown that rapid rotation leads to rotational distortion of the stellar surface, resulting in the appearance of non-radial ...
Cariková, Zuzana, Skopal, Augustin
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Two-component magnetohydrodynamical outflows around young stellar objects Interplay between stellar magnetospheric winds and disc-driven jets

, 2006
We present the first-ever simulations of non-ideal magnetohydrodynamical (MHD) stellar magnetospheric winds coupled with disc-driven jets where the resistive and viscous accretion disc is self-consistently described.
Anderson, Anderson, Bacciotti, Beristain, Blandford, Bogovalov, Brackbill, Burrows, C. Sauty, Casse, Casse, Casse, Coffey, Contopoulos, Cranmer, Cranmer, Dupree, F. Casse, Feigelson, Fender, Fendt, Fendt, Ferreira, Ferreira, Ferreira, Goldstein, Guentther, Gullburing, Kato, Kitchatinov, Koide, Koide, Kuwabara, Kwan, Königl, Leamon, Livio, Lubow, Matt, Matt, Meier, Mirabel, Mirabel, Ogilvie, Ouyed, Pelletier, Pouquet, Pudritz, Pudritz, Renaud, Sakurai, Sauty, Sauty, Sauty, Shakura, Smith, Sol, Tóth, Tóth, Ustyugova, Vlahakis, Von Rekowski, Wardle, Z. Meliani   +63 more
core   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Aperture and Resolution Effects on Ultraviolet Star-forming Properties: Insights from Local Galaxies and Implications for High-redshift Observations

The Astrophysical Journal
We present an analysis of the effects of spectral resolution and aperture scale on derived galaxy properties using far-ultraviolet (FUV) spectra of local star-forming galaxies from the International Ultraviolet Explorer ( R ∼ 250, field of view (FOV ...
Ilyse Clark, Danielle A. Berg, Claus Leitherer, Karla Z. Arellano-Córdova, Andreas A. C. Sander   +4 more
doaj   +1 more source

Energetics of star–planet magnetic interactions

Astronomy & Astrophysics
Context. Star–planet magnetic interactions (SPMIs) occurring in the sub-Alfvénic regime can, in principle, induce stellar chromospheric hotspots. These hotspots could serve as observational markers for inferring key planetary properties, especially the ...
Paul Arghyadeep, Strugarek Antoine
doaj   +1 more source

The sculpting of rectangular and jet-like morphologies in supernova remnants by anisotropic equatorially confined progenitor stellar winds [PDF]

, 2023
P. F. Velázquez, D M-A Meyer, A. Chiotellis, A E Cruz-Álvarez, M. Schneiter, Juan C. Toledo-Roy, E. M. Reynoso, A. Esquivel   +7 more
openalex   +1 more source

Properties of interstellar wind leading to shape morphology of the dust surrounding HD 61005

, 2017
A structure formed by dust particles ejected from the debris ring around HD 61005 is observed in the scattered light. The main aim here is to constrain interstellar wind parameters that lead to shape morphology in the vicinity of HD 61005 using currently
Pastor, P.
core   +1 more source