Results 81 to 90 of about 92,514 (295)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Observations of Extremely Metal-poor O Stars: Weak Winds and Constraints for Evolution Models

The Astrophysical Journal
Metal-poor massive stars drive the evolution of low-mass galaxies, both locally and at high redshift. However, quantifying the feedback they impart to their local surroundings remains uncertain because models of stellar evolution, mass loss, and ionizing
O. Grace Telford, John Chisholm, Andreas A. C. Sander, Varsha Ramachandran, Kristen B. W. McQuinn, Danielle A. Berg   +5 more
doaj   +1 more source

Is the Wind of the Galactic Oe Star HD 155806 Magnetically Confined?

, 2010
Spectropolarimetric observations of HD 155806 - the hottest Galactic Oe star - were obtained with CFHT/ESPaDOnS to test the hypothesis that disk signatures in its spectrum are due to magnetic channeling and confinement of its stellar wind.
Alex W. Fullerton, Gregg A. Wade, Hubrig, Hubrig, Nazé, Stefano Bagnulo, Véronique Petit   +6 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Testing the Rossby Paradigm: Weakened Magnetic Braking in Early K-type Stars

The Astrophysical Journal
There is an intricate relationship between the organization of large-scale magnetic fields by a stellar dynamo and the rate of angular momentum loss due to magnetized stellar winds. An essential ingredient for the operation of a large-scale dynamo is the
Travis S. Metcalfe, Pascal Petit, Jennifer L. van Saders, Thomas R. Ayres, Derek Buzasi, Oleg Kochukhov, Keivan G. Stassun, Marc H. Pinsonneault, Ilya V. Ilyin, Klaus G. Strassmeier, Adam J. Finley, Rafael A. García, Daniel Huber, Yuxi (Lucy) Lu, Victor See   +14 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Chemical Self-Enrichment of HII Regions by the Wolf-Rayet Phase of an 85 Msun star

, 2006
It is clear from stellar evolution and from observations of WR stars that massive stars are releasing metal-enriched gas through their stellar winds in the Wolf-Rayet phase.
Abbott, Anders, Chiosi, D. Kröger, Dray, Dray, Esteban, Freyer, Freyer, G. Hensler, Hirschi, Hirschi, Kunth, Schaller, T. Freyer   +14 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Inferring the physics of protoplanetary disc evolution from the irradiated Cygnus OB2 region

Astronomy & Astrophysics
Context. Determining the physical processes driving protoplanetary disc evolution is of paramount importance for understanding planet formation. Our current understanding has crystallised around two possible evolution scenarios: turbulent viscosity and ...
Weder Jesse, Winter Andrew J., Mordasini Christoph   +2 more
doaj   +1 more source