Results 211 to 220 of about 1,100,727 (344)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

History of individual presolar SiC grains revealed by stellar winds. [PDF]

Nat Commun
Bajo KI, Izumi T, Otsuki Y, Amari S, Yurimoto H.   +4 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Jupiter Science Enabled by ESA's Jupiter Icy Moons Explorer. [PDF]

Space Sci Rev, 2023
Fletcher LN, Cavalié T, Grassi D, Hueso R, Lara LM, Kaspi Y, Galanti E, Greathouse TK, Molyneux PM, Galand M, Vallat C, Witasse O, Lorente R, Hartogh P, Poulet F, Langevin Y, Palumbo P, Gladstone GR, Retherford KD, Dougherty MK, Wahlund JE, Barabash S, Iess L, Bruzzone L, Hussmann H, Gurvits LI, Santolik O, Kolmasova I, Fischer G, Müller-Wodarg I, Piccioni G, Fouchet T, Gérard JC, Sánchez-Lavega A, Irwin PGJ, Grodent D, Altieri F, Mura A, Drossart P, Kammer J, Giles R, Cazaux S, Jones G, Smirnova M, Lellouch E, Medvedev AS, Moreno R, Rezac L, Coustenis A, Costa M.   +49 more
europepmc   +1 more source

Bright OB stars in the Galaxy IV. Stellar and wind parameters of early to late B supergiants [PDF]

, 2007
N. Markova, J. Puls
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

The emergence of globular clusters and globular-cluster-like dwarfs. [PDF]

Nature
Taylor ED, Read JI, Orkney MDA, Kim SY, Pontzen A, Agertz O, Rey MP, Andersson EP, Collins MLM, Yates RM.   +9 more
europepmc   +1 more source

Cosmic ray feedback in galaxies and galaxy clusters: A pedagogical introduction and a topical review of the acceleration, transport, observables, and dynamical impact of cosmic rays. [PDF]

Astron Astrophys Rev, 2023
Ruszkowski M, Pfrommer C.
europepmc   +1 more source

Stellar Winds and Mass-Loss Rates from Be Stars [PDF]

, 1982
Theodore P. Snow
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source