Results 81 to 90 of about 1,317,911 (218)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Stem Cells [PDF]

Neuro-Oncology, 2010
L. Cheng, Z. Huang, W. Zhou, Q. Wu, J. Rich, S. Bao, P. Baxter, H. Mao, X. Zhao, Z. Liu, Y. Huang, H. Voicu, S. Gurusiddappa, J. M. Su, L. Perlaky, R. Dauser, H.-c. E. Leung, K. M. Muraszko, J. A. Heth, X. Fan, C. C. Lau, T.-K. Man, M. Chintagumpala, X.-N. Li, P. Clark, M. Zorniak, Y. Cho, X. Zhang, D. Walden, E. Shusta, J. Kuo, S. Sengupta, S. Goel-Bhattacharya, S. Kulkarni, B. Cochran, C. Cusulin, A. Luchman, S. Weiss, M. Wu, N. Fernandez, S. Agnihotri, R. Diaz, J. Rutka, M. Bredel, J. Karamchandani, S. Das, B. Day, B. Stringer, F. Al-Ejeh, M. Ting, J. Wilson, K. Ensbey, P. Jamieson, Z. Bruce, Y. C. Lim, C. Offenhauser, S. Charmsaz, L. Cooper, J. Ellacott, A. Harding, J. Lickliter, P. Inglis, B. Reynolds, D. Walker, M. Lackmann, A. Boyd, A. Berezovsky, L. Poisson, L. Hasselbach, S. Irtenkauf, A. Transou, T. Mikkelsen, A. C. deCarvalho, D. Emlet, C. Del Vecchio, P. Gupta, G. Li, S. Skirboll, A. Wong, J. Figueroa, T. Shahar, A. Hossain, F. Lang, S. Fouse, J. Nakamura, C. D. James, S. Chang, J. Costello, J. M. Frerich, S. Rahimpour, Z. Zhuang, J. D. Heiss, A. Golebiewska, D. Stieber, L. Evers, E. Lenkiewicz, N. H. C. Brons, N. Nicot, A. Oudin, S. Bougnaud, F. Hertel, R. Bjerkvig, M. Barrett, L. Vallar, S. P. Niclou, X. Hao, J. Rahn, E. Ujack, X. Lun, G. Cairncross, S. Weiss, D. Senger, S. Robbins, J. Harness, R. Lerner, Y. Ihara, R. Santos, J. D. L. Torre, A. Lu, T. Ozawa, T. Nicolaides, D. James, C. Petritsch, D. Higgins, M. Schroeder, B. Ball, B. Milligan, F. Meyer, J. Sarkaria, J. Henley, W. Flavahan, Q. Wu, M. Hitomi, N. Rahim, Y. Kim, A. Sloan, R. Weil, I. Nakano, J. Sarkaria, B. Stringer, M. Li, J. Lathia, J. Rich, A. Hjelmeland, M. Kaluzova, S. Platt, M. Kent, A. Bouras, R. Machaidze, C. Hadjipanayis, S.-G. Kang, S.-H. Kim, Y.-M. Huh, E.-H. Kim, E.-K. Park, J. H. Chang, S. H. Kim, Y. K. Hong, D. S. Kim, S.-J. Lee, E. H. Kim, S. G. Kang, M. Hitomi, L. Deleyrolle, M. Sinyuk, M. Li, W. Goan, B. Otvos, M. Rohaus, M. Oli, V. Vedam-Mai, D. Schonberg, Q. Wu, J. Rich, B. Reynolds, J. Lathia, S.-T. Lee, K. Chu, S.-H. Kim, S. K. Lee, M. Kim, J.-K. Roh, R. Lerner, A. Griveau, Y. Ihara, B. Reichholf, M. McMahon, D. Rowitch, D. James, C. Petritsch, R. Nitta, S. Mitra, M. Agarwal, T. Bui, G. Li, J. Lin, C. Adamson, J. Martinez-Quintanilla, S.-H. Choi, D. Bhere, A. Shavkunov, R. Spelat   +201 more
openaire   +3 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source