Results 1 to 10 of about 22,659 (119)

Molecular monitoring of T-cell kinetics and migration in severe neurotoxicity after real-world CD19-specific chimeric antigen receptor T cell therapy

Haematologica, 2022
CD19-specific chimeric antigen receptor (CD19-CAR) T-cell therapies mediate durable responses in late-stage B-cell malignancies, but can be complicated by a potentially severe immune effector cell-associated neurotoxicity syndrome (ICANS). Despite broad
Susanna Carolina Berger, Boris Fehse, Nuray Akyüz, Maria Geffken, Christine Wolschke, Dietlinde Janson, Nico Gagelmann, Marlene Luther, Dominic Wichmann, Christian Frenzel, Guenther Thayssen, Anna Alegiani, Anita Badbaran, Silke Zeschke, Judith Dierlamm, Nicolaus Kröger, Francis A. Ayuk   +16 more
doaj   +1 more source

Spontaneous Complete Remission of Acute Myeloid Leukemia in the Absence of Disease-Modifying Therapy following Severe Pulmonary Involvement by Coronavirus Infectious Disease-19

Case Reports in Hematology, 2022
Coronavirus infectious disease-19 (COVID-19) usually alters the innate and adaptive immune setting by excessive production of proinflammatory cytokines, leading to a deviation in the natural course of simultaneous malignant disease.
Maryam Barkhordar, Fatemeh Tajic Rostami, Marjan Yaghmaie, Mehrdad Abbaszadeh, Bahram Chahardouli, Seied Asadollah Mousavi   +5 more
doaj   +1 more source

Comparison of immune reconstitution between anti-T-lymphocyte globulin and posttransplant cyclophosphamide as acute graft-versus-host disease prophylaxis in allogeneic myeloablative peripheral blood stem cell transplantation

Haematologica, 2021
Anti-T-cell lymphocyte globulin (ATLG) and posttransplant cyclophosphamide (PTCy) are now widely used strategies to prevent graft-versus-host disease (GVHD) after allogeneic stem cell transplantation.
Radwan Massoud, Nico Gagelmann, Ulrike Fritzsche-Friedland, Gaby Zeck, Silke Heidenreich, Christine Wolschke, Francis Ayuk, Maximilian Christopeit, Nicolaus Kröger   +8 more
doaj   +1 more source

Targeting CD38 in acute myeloid leukemia interferes with leukemia trafficking and induces phagocytosis

Scientific Reports, 2021
Targeting the interaction between leukemic cells and the microenvironment is an appealing approach to enhance the therapeutic efficacy in acute myeloid leukemia (AML).
Meike Farber, Yiyang Chen, Lucas Arnold, Michael Möllmann, Eva Boog-Whiteside, Yu-An Lin, H. Christian Reinhardt, Ulrich Dührsen, Maher Hanoun   +8 more
doaj   +1 more source

Improved outcomes of high-risk relapsed Hodgkin lymphoma patients after high-dose chemotherapy: a 15-year analysis

Haematologica, 2021
High-dose chemotherapy and autologous stem-cell transplant (HDC/ASCT) is standard treatment for chemosensitive relapsed classical Hodgkin lymphoma, although outcomes of high-risk relapse (HRR) patients remain suboptimal.
Yago Nieto, Stephen Gruschkus, Benigno C. Valdez, Roy B. Jones, Paolo Anderlini, Chitra Hosing, Uday Popat, Muzaffar Qazilbash, Partow Kebriaei, Amin Alousi, Neeraj Saini, Samer Srour, Katayoun Rezvani, Jeremy Ramdial, Melissa Barnett, Alison Gulbis, Terri Lynn Shigle, Sairah Ahmed, Swaminathan Iyer, Hun Lee, Ranjit Nair, Simrit Parmar, Raphael Steiner, Bouthaina Dabaja, Chelsea Pinnix, Jillian Gunther, Branko Cuglievan, Kris Mahadeo, Sajad Khazal, Hubert Chuang, Richard Champlin, Elizabeth J. Shpall, Borje S. Andersson   +32 more
doaj   +1 more source

Risk assessment for newly diagnosed, fit and young patients with Multiple Myeloma, in the era of novel treatment modalities: Are there any additional factors to be under consideration?

Hematology, Transfusion and Cell Therapy, 2022
Objective: Multiple myeloma (MM) is considered a disease of elderlies however, 35-40% of newly diagnosed MM (NDMM) patients (pts) are ≤60 years (ys) old.
Panayotis Kaloyannidis, Fatema Abdulla, Enas Mutahar, Haidar Hashim, Salman Harbi, Analie Estanislao, Solaf Ka   +6 more
doaj   +1 more source

Erythropoietin in stem cell transplantation [PDF]

Bone Marrow Transplantation, 2001
Anemia is universal after allogeneic and autologous stem cell transplantation, with both increased red cell utilization and decreased production playing a role. This anemia sometimes is associated with a relative erythropoietin deficiency. In allogeneic stem cell transplantation, randomized trials have demonstrated improved erythropoiesis and a ...
C B, Miller, H M, Lazarus
openaire   +2 more sources

Antibody response after vaccination against SARS-CoV-2 in adults with hematological malignancies: a systematic review and meta-analysis

Haematologica, 2021
Vaccines against SARS-CoV-2 have shown remarkable efficacy and thus constitute an important preventive option against coronavirus disease 2019 (COVID-19), especially in fragile patients.
Nico Gagelmann, Francesco Passamonti, Christine Wolschke, Radwan Massoud, Christian Niederwieser, Raissa Adjallé, Barbara Mora, Francis Ayuk, Nicolaus Kröger   +8 more
doaj   +1 more source

Donor Lymphocyte Infusion and Molecular Monitoring for Relapsed Myelofibrosis After Hematopoietic Cell Transplantation

HemaSphere, 2023
Hematopoietic cell transplantation (HCT) is a curative approach for myelofibrosis patients, but relapse is a major cause of treatment failure. We investigated the effect of donor lymphocyte infusion (DLI) in 37 patients with molecular (n = 17) or ...
Nico Gagelmann, Christine Wolschke, Anita Badbaran, Dietlinde Janson, Carolina Berger, Evgeny Klyuchnikov, Francis Ayuk, Boris Fehse, Nicolaus Kröger   +8 more
doaj   +1 more source

One novel ACOT7–NPHP4 fusion gene identified in one patient with acute lymphoblastic leukemia: a case report

BMC Medical Genomics, 2022
Background Acute lymphoblastic leukemia (ALL) is a type of heterogeneous hematopoietic malignancy that accounts for approximately 20% of adult ALL. Although ALL complete remission (CR) rate has increased to 85–90% after induction chemotherapy, 40–50% of ...
Xin Zong, Zhijie Kang, Dan Huang, Xuehong Zhang, Yuan Gao, Haina Wang, Weiling Li, Jinsong Yan   +7 more
doaj   +1 more source