Results 31 to 40 of about 1,463,285 (410)

Current status of autologous stem cell transplantation for multiple myeloma

Blood Cancer Journal, 2019
More than 30 years after its introduction, autologous stem cell transplantation (ASCT) remains the standard of care for young patients with newly diagnosed multiple myeloma. Not only did the arrival of novel agents such as immunomodulatory drugs (IMiDs),
Rama Al Hamed, A. Bazarbachi, F. Malard, J. Harousseau, M. Mohty   +4 more
semanticscholar   +1 more source

Current Status and Future Development of Cell Transplantation Therapy for Periodontal Tissue Regeneration [PDF]

, 2012
It has been shown that stem cell transplantation can regenerate periodontal tissue, and several clinical trials involving transplantation of stem cells into human patients have already begun or are in preparation.
Ishikawa, Isao, Iwata, Takanori, Okano, Teruo, Washio, Kaoru, Yoshida, Toshiyuki   +4 more
core   +3 more sources

The genomic analysis brings a new piece to the molecular jigsaw of idiopathic erythrocytosis

Experimental Hematology & Oncology, 2022
Erythrocytosis is a clinical condition characterized by increased red cell mass, hemoglobin, and hematocrit values. A significant fraction of patients is described as having idiopathic erythrocytosis.
Antonella Zagaria, Francesco Tarantini, Paola Orsini, Luisa Anelli, Cosimo Cumbo, Nicoletta Coccaro, Giuseppina Tota, Crescenzio Francesco Minervini, Elisa Parciante, Maria Rosa Conserva, Immacolata Redavid, Alessandra Ricco, Immacolata Attolico, Giorgina Specchia, Pellegrino Musto, Francesco Albano   +15 more
doaj   +1 more source

Selection of Suitable Alternative Donor in the Absence of Matched Sibling Donor: A Retrospective Single-Center Study to Compare between Haploidentical, 10/10 and 9/10 Unrelated Donor Transplantation

International Journal of Hematology-Oncology and Stem Cell Research, 2021
Background: Finding a suitable donor at the optimal time is one of the most challenging issues in many transplant centers. We evaluated the clinical outcomes of 248 patients with acute leukemia and without matched sibling donors (MSD) who underwent ...
Maryam Barkhordar, Amir Kasaeian, Seied Asadollah Mousavi, Sahar Tavakoli, Mohammad Vaezi, Hosein Kamranzadeh Foumani, Tanaz Bahri, Davood Babakhani, Leila Mirzakhani, Ashraf Mousavi, Ardeshir Ghavamzadeh   +10 more
doaj   +1 more source

Dynamical System Modeling to Simulate Donor T Cell Response to Whole Exome Sequencing-Derived Recipient Peptides: Understanding Randomness in Clinical Outcomes Following Stem Cell Transplantation [PDF]

PLoS One. 2017 Dec 1;12(12):e0187771, 2016
Alloreactivity following stem cell transplantation (SCT) is difficult to predict in patients undergoing transplantation from HLA matched donors. In this study we performed whole exome sequencing of SCT donor-recipient pairs (DRP). This allowed determination of entire library of alloreactive peptide sequences which would bind HLA class I molecules in ...
arxiv   +1 more source

FLT3-ITD Compared with DNMT3A R882 Mutation Is a More Powerful Independent Inferior Prognostic Factor in Adult Acute Myeloid Leukemia Patients After Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Cohort Study

Turkish Journal of Hematology, 2018
Objective: This study aimed to evaluate DNMT3A exon 23 mutations and their prognostic impacts in the presence of NPM1 and FLT3 mutations in acute myeloid leukemia (AML) patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT ...
Majid Teremmahi Ardestani, Ahmad Kazemi, Bahram Chahardouli, Saeed Mohammadi, Mohsen Nikbakht, Shahrbano Rostami, Mahdi Jalili, Mohammad Vaezi, Kamran Alimoghaddam, Ardeshir Ghavamzadeh   +9 more
doaj   +1 more source

Targeting autophagy increases the efficacy of proteasome inhibitor treatment in multiple myeloma by induction of apoptosis and activation of JNK

BMC Cancer, 2022
Background The therapeutic armamentarium in multiple myeloma has been significantly broadened by proteasome inhibitors, highly efficient means in controlling of multiple myeloma.
Azam Salimi, Kema Marlen Schroeder, Mirle Schemionek-Reinders, Margherita Vieri, Saskia Maletzke, Deniz Gezer, Behzad Kharabi Masouleh, Iris Appelmann   +7 more
doaj   +1 more source

MLL-SEPT5 Fusion Transcript in Myelodysplastic Syndrome Patient With t(11;22)(q23;q11)

Frontiers in Medicine, 2021
Objectives: This study aimed to identify unknown mixed lineage leukemia (MLL) translocation partner genes in a de novo patient with myelodysplastic syndrome (MDS) with t(11;22)(q23;q11) and investigate the clinical and molecular features of this patient ...
Duobing Zou, Ying Chen, Ningning Wu, Yi Zhang, Guifang Ouyang, Qitian Mu   +5 more
doaj   +1 more source

Clonal Dominance and Transplantation Dynamics in Hematopoietic Stem Cell Compartments [PDF]

PLoS Comput Biol 13(10): e1005803 (2017), 2017
Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. Experimental findings have suggested that they exist in a dynamic equilibrium, continuously migrating between these two compartments.
arxiv   +1 more source

A general practitioner's guide to hematopoietic stem-cell transplantation.

Current Oncology, 2019
Hematopoietic stem-cell transplantation (hsct) is a medical procedure that consists of infusing stem cells after a short course of chemotherapy or radiotherapy, or both.
A. Bazinet, G. Popradi
semanticscholar   +1 more source