Results 61 to 70 of about 5,922,427 (309)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Three-dimensional culture of human embryonic stem cell derived hepatic endoderm and its role in bioartificial liver construction [PDF]

, 2010
The liver carries out a range of functions essential for bodily homeostasis. The impairment of liver functions has serious implications and is responsible for high rates of patient morbidity and mortality.
Greenhough, Sebastian, Medine, Claire N, Hay, David C; id_orcid, Sharma, Ruchi   +3 more
core   +1 more source

Autologous stem cell transplantation for malignancy: a systematic review of the literature

, 2000
A systematic review of the literature was undertaken to assess what published evidence is currently available to support the increasing use of autologous stem cell transplantation (ASCT), and to evaluate the published data with regard to the comparative ...
Simnett, S.J., Stewart, L. A., Johnson, Peter W.M., Morgan, G., Sweetenham, J.   +4 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cell-free Embryonic Stem Cell Extract-mediated Derivation of Multi-potent Stem Cells from NIH3T3 Fibroblasts for Functional and Anatomical Ischemic Tissue Repair [PDF]

, 2007
The oocyte-independent generation of multipotent stem cells is one of the goals in regenerative medicine. We report that upon exposure to mouse ES cell (ESC) extracts, reversibly permeabilized NIH3T3 cells undergo de-differentiation followed by stimulus ...
Erin Lambers, Johnson Rajasingh, Hiromichi Hamada, Deepali Ahluwalia, Tina Thorne, Ilona Goukassian, Kenneth M. Rosen, Yan Zhu, Douglas W. Losordo, Evelyn Bord, Prasanna Krishnamurthy, Gangjian Qin, Karen Schlauch, Raj Kishore   +13 more
core  

Haematopoietic cell transplantation in Switzerland, changes and results over 20 years: a report from the Swiss Blood Stem Cell Transplantation Working Group for Blood and Marrow Transplantation registry 1997-2016 [PDF]

, 2018
In 1997, the Swiss Blood Stem Cell Transplantation Group (SBST) initiated a mandatory national registry for all haematopoietic stem cell transplants (HCTs) in Switzerland.
Bargetzi, M., Kurt Leibundgut, Passweg, J.R., Renner, Christoph, Chalandon, Yves, Leibundgut, K., Leibundgut, Kurt, Grazia Nicoloso de Faveri, Swiss Blood Stem Cell Transplantation Group, SBST, Thomas Pabst, Christoph Renner, Duchosal, M.A., Baerlocher, Gabriela M, Nair, Gayathri, Ansari, M., Renner, C., Passweg, Jakob R, Sabine Gerull, Hess-Kappas, Ursula, Schanz, U., Schmidt, Adrian, Jakob R. Passweg, Gerull, S., Adrian Schmidt, Pabst, Thomas, Tayfun Güngör, Yves Chalandon, Nair, G., Urs Hess, Antonia Müller, Chalandon, Y., Nicoloso de Faveri, G., Duchosal, Michel A, Müller, Antonia, Masouridi Levrat, Stavroula, Ansari Djaberi, Marc Georges, Masouridi-Levrat, Stavroula, Heim, D., Müller, A., Halter, J.P., Baldomero, H., Masouridi-Levrat, S., Gabriela M. Baerlocher, Bargetzi, Mario, Stussi, Georg, Georg Stussi, Dominik Heim, Jörg P. Halter, Schanz, Urs, Marc Ansari, Michel A. Duchosal, Baerlocher, Gabriela M., Helen Baldomero, Ansari, Marc, Güngör, T., Halter, Jörg P, Nicoloso de Faveri, Grazia, Baerlocher, G.M., Gayathri Nair, Schmidt, A., Pabst, T., Urs Schanz, Stussi, G., Gerull, Sabine, Güngör, Tayfun, Stavroula Masouridi-Levrat, Mario Bargetzi, for the Swiss Blood Stem Cell Transplantation Group (SBST), Baldomero, Helen, Heim, Dominik, Hess, U., Hess, Urs   +71 more
core   +2 more sources

A unique case of durable complete remission after salvage with azacitidine and DLI for high risk flt-3 positive acute myeloid leukemia, following relapse 18 months post allogeneic stem cell transplant

Hematology Reports, 2019
A unique case of primary refractory FLT3-itd mutated acute myeloid leukemia in an elderly patient, who achieved completed morphological remission, and FLT3-itd negativity, following 9 cycles of azacitadine in combination with escalating doses of donor ...
Claire Horgan, Alexandros Kanellopoulos, Shankara Paneesha, Bhuvan Kishore, Richard Lovell, Emmanouil Nikolousis   +5 more
doaj   +1 more source

Stem cells and stem cell transplantation.

Haematologica, 1997
Stem cell transplantation (SCT) is an increasingly used therapeutic approach for the treatment of hematological and non-hematological disease of neoplastic and non-neoplastic origin. How the phenomena controlling blood cell production take place during SCT is still largely unclear.
C, Carlo-Stella, A, Tabilio
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

ERRATUM: A unique case of durable complete remission after salvage with azacitidine and DLI for high risk flt-3 positive acute myeloid leukemia, following relapse 18 months post allogeneic stem cell transplant

Hematology Reports, 2020
Due to an error, Dr. Nikolousis’s last name was mistakenly spelled in this article (published in 2019 in Hematology Reports DOI: 10.4081/hr.2019.7800). The correct author’s name appears above in italics.
Claire Horgan, Alexandros Kanellopoulos, Shankara Paneesha, Bhuvan Kishore, Richard Lovell, Emmanouil Nikolousis   +5 more
doaj   +1 more source