Results 71 to 80 of about 37,507 (250)

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

Construction of Nano-Assembled Microcapsules Embedded with Gold Nanoparticles for use in Novel Drug Delivery Systems [PDF]

arXiv, 2016
Coronary stents have changed the way in which coronary artery diseases are managed. Although bare-metal stents can be traced back to 1994, long term efficacy of these stents has been shattered by ISR (In-Stent restenosis) and late stent thrombosis. Research on finding a solution to these issues has led to the development of DESs (Drug eluting stents ...
arxiv  

Advancements in Bio‐Integrated Flexible Electronics for Hemodynamic Monitoring in Cardiovascular Healthcare

Advanced Science, EarlyView.
This review explores the cutting‐edge development of bio‐integrated flexible electronics for real‐time hemodynamic monitoring in cardiovascular healthcare. It covers key physiological indicators, innovative sensing mechanisms, and materials considerations. This paper highlights the application of both invasive and non‐invasive devices in cardiovascular
Ke Huang, Zhiqiang Ma, Bee Luan Khoo
wiley   +1 more source

Anti-platelet drugs, pharmacogenomics and stent thrombosis: What’s new?

SA Heart Journal, 2017
Stent thrombosis is a catastrophic complication of percutaneous coronary intervention (PCI) and is associated with a mortality of 25 to 40%. The perception that stent thrombosis is very low in all patients has resulted in a lack of adherence to ...
John Benjamin
doaj   +1 more source

Uncertainty quantification of a thrombosis model considering the clotting assay PFA-100 [PDF]

arXiv, 2021
Mathematical models of thrombosis are currently used to study clinical scenarios of pathological thrombus formation. Most of these models involve inherent uncertainties that must be assessed to increase the confidence in model predictions and identify avenues of improvement for both thrombosis modeling and anti-platelet therapies.
arxiv  

Functional Complete Revascularization as Determined by an Optimized Scoring System After Revascularization: A Post Hoc Analysis from Multi‐Center PANDA III Trial

Advanced Science, Volume 12, Issue 14, April 10, 2025.
The modified residual functional SYNTAX score (m‐rFSS) algorithm was updated for 2 clinical scenarios: 1) lesions with suboptimal functional results, and 2) angiographic diameter stenosis <50% but functionally significant stenoses, which were not scored by classic rFSS or rSS.
Rui Zhang, Shaoyu Wu, Qianqian Liu, Changdong Guan, Hao‐Yu Wang, Sheng Yuan, Lihua Xie, Yunfei Huang, Zheng Qiao, Weida Liu, Rui Fu, Lei Feng, Chenggang Zhu, Lei Song, Dong Yin, Kefei Dou   +15 more
wiley   +1 more source

A New Concept for Carotid Artery Stenting: Coating the Atherosclerotic Plaque by Covered Stent before Bare Stent Implantation

Case Reports in Neurological Medicine, 2016
In carotid artery stenting (CAS) procedures, distal embolism, periprocedural stent thrombosis, and 30-day stroke due to the plaque fragmentation and protrusion caused by stent implantation and balloon dilation are frequent complications.
Erol Akgul
doaj   +1 more source

Biodegradable drug eluting coating of cardiovascular stents dewets and can cause thrombosis [PDF]

arXiv, 2011
The results of our investigation of ion implantation of PLGA show that the PLGA films undergo crosslinking, carbonization and etching. The PLGA coating degrades in water by a hydrolysis reaction. The dewetting of PLGA coating under water is observed on silicon wafer, metal and carbon surfaces. As the result, the coating is ruptured up to separate drops
arxiv  

Finite element modelling of in-stent restenosis [PDF]

arXiv, 2020
From the perspective of coronary heart disease, the development of stents has come significantly far in reducing the associated mortality rate, drug-eluting stents being the epitome of innovative and effective solutions. Within this work, the intricate process of in-stent restenosis is modelled considering one of the significant growth factors and its ...
arxiv