Results 51 to 60 of about 515,177 (266)

A STEP-NC implementation approach for additive manufacturing

Procedia Manufacturing, 2019
Abstract This paper describes an approach for implementing the STEP-NC standard in additive manufacturing. Geometric information of additive manufacturing layers is used as input data to generate the STEP-NC program according to ISO 10303 AP-238.
Efrain Rodriguez, Alberto Alvares
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Toolpaths Programming in an Intelligent Step-NC Manufacturing Context

, 2008
The current language for CNC programming is G-code which dates from the beginning of the eighties with the norm ISO 6983. With the new technologies, G-code becomes obsolete. It presents drawbacks that create a rupture in the numerical chain at the manufacturing step. A new standard, STEP-NC, aims to overtake these lacks. A STEP-NC file includes all the
Laguionie, Raphael, Rauch, Matthieu, Hascoët, Jean-Yves   +2 more
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Thermal decomposition kinetics and storage life prediction of nitramine propellants with different energetic plasticizers based on model-fitting method

Case Studies in Thermal Engineering
The research on the thermal decomposition of propellant is critical to determining its safe storage life. The thermogravimetry (TG) testing of nitramine propellants plasticized by nitroglycerin (NG), glycidyl azide polymer (GAP), 2,2-dinitropropanol ...
You Fu, Zhitao Liu, Bin Xu, Feiyun Chen, Xiaoan Wei, Yiqiang Long, Xin Liao   +6 more
doaj   +1 more source

Ink-lithographic fabrication of silver-nanocrystal-based multiaxial strain gauge sensors through the coffee-ring effect for voice recognition applications

Nano Convergence, 2022
Human voice recognition techniques have remarkable potential for clinical applications because information from acoustic signals can reflect human body conditions. This paper reports the fabrication of Ag nanocrystal (NC)-based multiaxial wearable strain
Junhyuk Ahn, Hyung Jin Choi, Junsung Bang, Gayeon Son, Soong Ju Oh   +4 more
doaj   +1 more source

ALGORITHM FOR ISO 14649 (STEP-NC) FEATURE RECOGNITION

Management and Production Engineering Review, 2013
Abstract The paper focuses on the algorithm for the recognition of manufacturing features defined in ISO 14649 (STEP-NC). First, the features defined in STEP-NC standard are discussed and then commonly used feature recognition methods are presented.
openaire   +1 more source

An overview on STEP-NC compliant controller development

IOP Conference Series: Materials Science and Engineering, 2017
The capabilities of conventional Computer Numerical Control (CNC) machine tools as termination organiser to fabricate high-quality parts promptly, economically and precisely are undeniable. To date, most CNCs follow the programming standard of ISO 6983, also called G & M code.
M A Othman, M Minhat, Z Jamaludin
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source