Results 101 to 110 of about 19,948,663 (200)
Innovation systems, innovation modes and processes of commercialization [PDF]
, 2008 The papers presented in this volume are the main results of a strategic institute program organised during 2006-2007 at NIFU STEP on “Innovation processes in an evolutionary perspective”.
Ørstavik, Finn +6 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A generalized additional voltage pumping solution for high-step-up converters
, 2019 This study develops a generalized additional voltage pumping solution (GAVPS) for a series of high-step-up converters, whose topologies can be modeled by a generalized architecture.
Samson Yu (13093116) +6 more
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Endoscopic “Step‑up” Treatment Approach for Walled off Pancreatic Necrosis
Journal of Digestive Endoscopy, 2017 Surinder Singh Rana, Sobur Uddin Ahmed
doaj +1 more source
Modern surgical treatment of elderly patients with choledocholithiasis and mechanical jaundice
Якутский медицинский журналA prospective analysis of diagnosis and treatment of the elderly and senile patients with acute cholecystitis complicated by choledocholithiasis and mechanical jaundice is carried out.
M. M. Vinokurov +8 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source