Results 211 to 220 of about 2,510,747 (268)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

The power of Network Pluralism: multi-perspective modeling of heterogeneous legal document networks. [PDF]

Eur Phys J B
Pünder T, Coupette C.
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

The Role of Worked Examples in Supporting Early Math Learning. [PDF]

J Intell
Stone T, Fish LR, Chernyak N, Guadalupe G, Cordes S.   +4 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

People Counting Using YOLO-Based Detection and Clustering for a Mobile Robot. [PDF]

Sensors (Basel)
Gomulka K, Wozniak P, Krzeszowski T.
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Adaptive Optics Image Analysis Using Generative AI (GPT-4) Scripting: Exploratory Study. [PDF]

JMIR Form Res
Pas JA, van der Zanden LC, van Leeuwen Y, Lechanteur YT, Hoyng CB, Theelen T.   +5 more
europepmc   +1 more source

Pictorial review: a step-by-step guide to coronary CT angiography with photon-counting detector CT. [PDF]

Br J Radiol
Xie C, Clarke N, Kotronias R, Chan K, Portolan L, Thomas S, Denton J, Farrall R, Taylor C, Jung CY, Halborg T, Nikolaidou C, Kelion A, Sabharwal N, Holdsworth D, Raman B, Neubauer S, Antoniades C.   +17 more
europepmc   +1 more source

Protocol to determine oligomerization states of proteins in living cells using photon counting histogram analysis. [PDF]

STAR Protoc
Li Z, Camp T, Li Y, Zhang K.
europepmc   +1 more source