Results 191 to 200 of about 25,208 (288)

Speech Biomarkers for Quantifying Effects of Subthalamic Deep Brain Stimulation in Parkinson's Disease

open access: yesAnnals of Neurology, EarlyView.
Objective Dysarthria is one of the most common and disabling side effects of subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson's disease (PD). Stimulation often exacerbates speech dysfunction beyond the effects of PD progression, likely because of current spread to structures surrounding the STN.
Petr Krýže   +17 more
wiley   +1 more source

Ketal Protection of Glycerol for Selective Electrosynthesis of Glyceric Acid in Highly Alkaline Media

open access: yesAngewandte Chemie, EarlyView.
Using a ketal‐protected glycerol derivative (solketal) as the oxidation substrate enables site‐selective electrooxidation that suppresses C–C cleavage on non‐noble catalysts. Highly alkaline conditions promote reactive solketal alkoxide formation, weaken the Cα─H bond to facilitate dehydrogenation, and buffer local acidification, enabling a record‐high
Jiamin Wang   +6 more
wiley   +2 more sources

Gut–Brain Axis Modulation by Short‐Chain Fatty Acids Exerts Disease‐Modifying Effects in a Murine Model of Drug‐Resistant Epilepsy

open access: yesAnnals of Neurology, EarlyView.
Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera   +16 more
wiley   +1 more source

Chelator‐Free Radiometal Labeling Inside Engineered Affibodies

open access: yesAngewandte Chemie, EarlyView.
Affibodies are compact and robust three‑helix binders used in imaging and therapy. Engineering a triple‑cysteine motif into their core enables chelator‑free binding of important radiometals, like Bi(III), Pb(II), In(III), and Ga(III) with rapid uptake and exceptional stability.
Lani J. Davies   +6 more
wiley   +2 more sources

Design, Implementation, and Verification of High-Accuracy Trapezoidal Dual-Axis Sun Sensors for LEO Satellite Attitude Determination. [PDF]

open access: yesSensors (Basel)
Ou-Yang M   +12 more
europepmc   +1 more source

Attractive Ni…O Interactions Enable Non‐Alternating Ethylene‐Carbon Monoxide Copolymerization

open access: yesAngewandte Chemie, EarlyView.
Attractive Ni···O interactions are established in phosphine‐imidated and phosphine‐phenolate nickel catalysts, enabling non‐alternating ethylene‐carbon monoxide copolymerization, resulting in superior CO tolerance, productivity and stability compared to the state‐of‐the‐art benchmark.
Yajun Zhao   +5 more
wiley   +2 more sources

Pyramid urethral mobilisation hypospadias repair for distal variant: experience with 70 cases. [PDF]

open access: yesFront Pediatr
Andriescu M   +4 more
europepmc   +1 more source

Copper(II/III) Redox Couple Enables C─H Methylation via a Radical Mechanism Analogous to SAM Enzymes

open access: yesAngewandte Chemie, EarlyView.
Biological C–H methylation proceeds through radical pathways mediated by one‐electron redox cofactors, yet no synthetic model has reproduced this reactivity. Here, we report the first isolable Cu(II/III)–methyl complexes that mediate C–H methylation through hydrogen atom transfer and methyl radical rebound.
Emily N. Doss   +2 more
wiley   +2 more sources

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