Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
BMC Family Practice, 2020 Background Clinician utilization of practice guidelines can reduce inappropriate opioid prescribing and harm in chronic non-cancer pain; yet, implementation of “opioid guidelines” is subpar. We hypothesized that a multi-component quality improvement (QI)
Aleksandra E. Zgierska +9 more
doaj +1 more source
Stepped-wedge cluster randomised controlled trials : a generic framework including parallel and multiple-level designs [PDF]
, 2014 Stepped-wedge cluster randomised trials (SW-CRTs) are being used with increasing frequency in health service evaluation. Conventionally, these studies are cross-sectional in design with equally spaced steps, with an equal number of clusters randomised at
Girling, Alan J. +2 more
core +2 more sources
Theory of general balance applied to step wedge designs [PDF]
Statistics in Medicine, 2018 A standard idealized step‐wedge design satisfies the requirements, in terms of the structure of the observation units, to be considered a balanced design and can be labeled as a criss‐cross design (time crossed with cluster) with replication. As such, Nelder's theory of general balance can be used to decompose the analysis of variance into independent ...
openaire +3 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
A Validation of Symmetric 2D + T Model Based on Single-Stepped Planing Hull Towing Tank Tests
Journal of Marine Science and Engineering, 2018 In the current article, the hydrodynamic forces of single-stepped planing hulls were evaluated by an analytical method and compared against towing tank tests.
Rasul Niazmand Bilandi +4 more
doaj +1 more source
The use of permutation tests for the analysis of parallel and stepped-wedge cluster randomized trials [PDF]
, 2016 We investigate the use of permutation tests for the analysis of parallel and stepped-wedge cluster randomized trials. Permutation tests for parallel designs with exponential family endpoints have been extensively studied.
DeGruttola, Victor, Wang, Rui
core +1 more source
Promoting Recruitment using Information Management Efficiently (PRIME): study protocol for a stepped wedge cluster randomised controlled trial within the REstart or STop Antithrombotics Randomised Trial (RESTART) [PDF]
, 2017 BACKGROUND: Research into methods to boost recruitment has been identified as the highest priority for randomised controlled trial (RCT) methodological research in the United Kingdom.
Dennis, Martin +5 more
core +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source