Results 101 to 110 of about 19,338 (286)

Leveraging Contact Network Structure in the Design of Cluster Randomized Trials [PDF]

, 2016
Background: In settings like the Ebola epidemic, where proof-of-principle trials have succeeded but questions remain about the effectiveness of different possible modes of implementation, it may be useful to develop trials that not only generate ...
DeGruttola, Victor, Harling, Guy, Onnela, Jukka-Pekka, Wang, Rui   +3 more
core   +3 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Participatory development and pilot testing of the Makasi intervention: a community-based outreach intervention to improve sub-Saharan and Caribbean immigrants’ empowerment in sexual health

BMC Public Health, 2019
Background Sub-Saharan and Caribbean immigrants are particularly affected by HIV in Europe, and recent evidence shows that a large portion of them acquired HIV after arrival.
Anne Gosselin, Séverine Carillon, Karna Coulibaly, Valéry Ridde, Corinne Taéron, Veroska Kohou, Iris Zouménou, Romain Mbiribindi, Nicolas Derche, Annabel Desgrées du Loû, for the MAKASI Study Group   +10 more
doaj   +1 more source

The effect of a complementary e-learning course on implementation of a quality improvement project regarding care for elderly patients: a stepped wedge trial [PDF]

, 2012
Background Delirium occurs frequently in elderly hospitalised patients and is associated with higher mortality, increased length of hospital stay, functional decline, and admission to long-term care.
CA Brown, Cordula Wagner, D Anderson, DA Cook, EJ Thomas, ER Marcantonio, HM Kruizenga, J McCusker, J Witlox, JG Bloomfield, K Irving, LA van Gemert, LH Moulton, Lotte Van de Steeg, M Abdolrasulnia, M Agar, M Zegers, MA Hussey, Maaike Langelaan, MC de Bruijne, ME Charlson, MG Cole, MJ Schuurmans, MJ Schuurmans, MT Vidán, N Steverink, N Tabet, ND Mdege, RJ Stratton, Roelie Ijkema, S Katz, SK Inouye, SK Inouye, SK Inouye, SK Inouye, V Mittal   +35 more
core   +4 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

CRTFASTGEEPWR: A SAS Macro for Power of Generalized Estimating Equations Analysis of Multi-Period Cluster Randomized Trials with Application to Stepped Wedge Designs

Journal of Statistical Software
Multi-period cluster randomized trials (CRTs) are increasingly used for the evaluation of interventions delivered at the group level. While generalized estimating equations (GEE) are commonly used to provide population-averaged inference in CRTs, there ...
Ying Zhang, John S. Preisser, Fan Li, Elizabeth L. Turner, Paul J. Rathouz   +4 more
doaj   +1 more source

Ethical Challenges of Randomized Violence Intervention Trials: Examining the SHARE intervention in Rakai, Uganda. [PDF]

, 2016
ObjectiveWe identify complexities encountered, including unanticipated crossover between trial arms and inadequate 'standard of care' violence services, during a cluster randomized trial (CRT) of a community-level intimate partner violence (IPV) and HIV ...
Nalugoda, Fred, Namatovu, Fredinah, Paul, Amy, Ssekubugu, Robert, Wagman, Jennifer A   +4 more
core   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Reducing Medical Admissions into Hospital through Optimising Medicines (REMAIN HOME) Study: Protocol for a stepped wedge, cluster randomised trial [PDF]

, 2017
Introduction: A model of general practitioner (GP) and pharmacist collaboration in primary care may be an effective strategy to reduce medication-related problems and provide better support to patients after discharge.
Arnold, Australian Council on Safety and Quality in Health Care, Belleli, Bonnet-Zamponi, Campbell, Campbell, Chan, Coleman, Davies, Freeman, Freeman, Hansen, Hawes, Hazen, Hemming, Hemming, Holland, Howell, Hussey, Independent Hospital Pricing Authority, Independent Hospital Pricing Authority, Jack, Jencks, Kilcup, Kwan, Leppin, Mekonnen, Mueller, Naunton, Pal, Picker, Polinski, Rockwood, Stowasser, Tan, Tedesco, Unroe, Van, Vashi, Williams, Wimmer   +40 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source