Results 111 to 120 of about 19,338 (286)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Longitudinal exploration of the delivery of care following a successful antenatal practice change intervention

Frontiers in Medicine
IntroductionThis is a secondary analysis of a stepped-wedge trial. The sustainment of evidence-based care is essential for ongoing population benefits.
Alix Hall, Alix Hall, Alix Hall, Emma Doherty, Emma Doherty, Emma Doherty, Nicole Nathan, Nicole Nathan, Nicole Nathan, John Wiggers, John Wiggers, John Wiggers, John Attia, John Attia, Belinda Tully, Belinda Tully, Belinda Tully, Elizabeth J. Elliott, Elizabeth J. Elliott, Christopher Oldmeadow, Christopher Oldmeadow, Simon Chiu, Simon Chiu, Melanie Kingsland, Melanie Kingsland, Melanie Kingsland   +25 more
doaj   +1 more source

The Devon Active Villages Evaluation (DAVE) trial: study protocol of a stepped wedge cluster randomised trial of a community-level physical activity intervention in rural southwest England [PDF]

, 2012
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.BACKGROUND: Although physical inactivity has been linked with numerous chronic health conditions and overall ...
Hillsdon, Melvyn, Metcalf, B, Rees, Tim, Solomon, Emma, Ukoumunne, Obioha C.   +4 more
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Core components for effective infection prevention and control programmes: new WHO evidence-based recommendations [PDF]

, 2017
Health care-associated infections (HAI) are a major public health problem with a significant impact on morbidity, mortality and quality of life. They represent also an important economic burden to health systems worldwide.
A Higgins, A Jamal, A Lipitz-Snyderman, A Pinto, AF Vicca, AJ Howie, AM Yinnon, AR Marra, AS Mathai, B Allegranzi, BA Mark, BN Reames, BS Koll, BW Thomas, C Brandt, C Fuller, CS Cocanour, D Fisher, D Pittet, D Pittet, D Quiros, DD Wirtschafter, DG Bundy, DJ Birnbach, DM Henderson, E Creamer, Effective Practice and Organisation of Care (EPOC), EG Shepherd, EL Geubbels, EL Larson, F L’Heriteau, F Schwab, G Pontivivo, GB Allen, GH Guyatt, HW Kilbride, I Zuschneid, International Health Regulations, J Alonso-Echanove, J Bion, J Blatnik, J Mayer, J Robert, JA Al-Tawfiq, JA Marsteller, JB Cunningham, JB Cunningham, JB Cunningham, JH Barsuk, JH Jang, JJ Anderson, JW Lederer Jr, KB Kirkland, KB Stevenson, L Bouadma, L Charrier, L Gerolemou, L Johnson, L Rubinson, LA Mermel, LJ Damschroder, LL McKinley, M Thomas, M Virtanen, M Whitby, MA Borg, MA Borg, MD Koff, ML Grayson, ML McLaws, ML McLaws, ML Render, ML Schweizer, MR Miller, MR Miller, N Petrosillo, P Eggimann, P Gastmeier, P Gastmeier, P Gastmeier, P Gastmeier, PW Nicol, R Jain, R Peredo, RJ Sherertz, RM Sladek, RW Haley, S Barwolff, S Hansen, S Hugonnet, S Hugonnet, S Hugonnet, S Newitt, S Nijssen, SA Creedon, SC Joshi, SI Doron, SK Fridkin, SM Brown, SR Lieber, TR Talbot, V Rodriguez, VA DePalo, VD Rosenthal, VD Rosenthal, VD Rosenthal, VD Rosenthal, W Moongtui, W Turnberg, W Zingg, W Zingg, W Zingg, WN Viana, YL Kwok   +113 more
core   +6 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

GeriMedRisk, a telemedicine geriatric pharmacology consultation service to address adverse drug events in long-term care: a stepped-wedge cluster randomized feasibility trial protocol (ISRCTN17219647)

Pilot and Feasibility Studies, 2018
Background Multimorbidity, polypharmacy, and older age predispose seniors to adverse drug events (ADE). Seniors with an ADE experience greater morbidity, mortality, and health care utilization compared to their younger counterparts.
Joanne Man-Wai Ho, Jennifer Tung, Janine Maitland, Derelie Mangin, Lehana Thabane, J. Michael Pavlin, Jeffrey Alfonsi, Anne Holbrook, Sharon Straus, Sophiya Benjamin   +9 more
doaj   +1 more source

Evaluating the impact of a community health worker program on non-communicable disease, malnutrition, tuberculosis, family planning and antenatal care in Neno, Malawi : protocol for a stepped-wedge, cluster randomized controlled trial [PDF]

, 2018
Introduction: This protocol concerns the implementation and evaluation of an intervention designed to realign the existing cadre of Community Health Workers (CHWs) in Neno District, Malawi to better support the care needs of the clients they serve.
Cundale, Katie, Dullie, Luckson, Dunbar , Elizabeth L., Gupta, Ravi, Jumbe, Arnold, Kachimanga, Chiyembekezo, Lilford, Richard, McBain, Ryan, Michaelis, Annie, Nazimera, Lawrence, Nhlema, Basimenye, Taylor, Celia A., Watson, Samuel I., Wroe, Emily B.   +13 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The Meta-Intelligent Child: Validating the MKIT as a Tool to Develop Metacognitive Knowledge in Early Childhood

Journal of Intelligence
This article presents and validates the Metacognitive Knowledge Intervention for Thinking (MKIT)—an educational framework designed to assess and develop domain-general metacognitive knowledge (MK) in children aged 5 to 9.
Onciu Oana, Prisacaru Flavia
doaj   +1 more source