Results 121 to 130 of about 19,338 (286)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Optimal allocation of clusters in stepped wedge designs with a decaying correlation structure

PLoS ONE, 2023
The cluster randomized stepped wedge design is a multi-period uni-directional switch design in which all clusters start in the control condition and at the beginning of each new period a random sample of clusters crosses over to the intervention ...
Mirjam Moerbeek
doaj  

Study Protocol for a Stepped-Wedge Randomized Cookstove Intervention in Rural Honduras: Household Air Pollution and Cardiometabolic Health [PDF]

, 2019
Growing evidence links household air pollution exposure from biomass-burning cookstoves to cardiometabolic disease risk. Few randomized controlled interventions of cookstoves (biomass or otherwise) have quantitatively characterized changes in exposure ...
Africano, Sebastian, Benka-Coker, Megan L., Brook, Robert, Clark, Maggie L., Good, Nicholas, Keller, Joshua P., L\u27Orange, Christian, Nelson, Tracy L., Osorto Pinel, Anibal, Peel, Jennifer L., Quinn, Casey, Rajkumar, Sarah, Volckens, John, Walker, Ethan S., Weller, Zachary D., Young, Bonnie N.   +15 more
core   +1 more source

Methodological progress note: Stepped‐wedge cluster randomized trial design

Journal of Hospital Medicine
Hospitalists are often involved in quality and research efforts to improve care delivery in the inpatient setting.1 To assess the effectiveness of these efforts, new healthcare delivery initiatives may be evaluated by comparing clinical outcomes between patients who received the intervention and those who received usual care, which is commonly used as ...
Alina G. Burek, Amanda Ullman, David C. Brousseau   +2 more
openaire   +3 more sources

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Power analysis for stepped wedge trials with delayed treatment initiation and longitudinal measurements [PDF]

, 2016
Stepped wedge trials (SWT) is a special type of crossover cluster randomized trials (CRT) in which clusters are randomized to initiate treatment at different points in time.
Liu, Peng
core  

Long‐Term Opioids in Gout: A Matched Cohort Study From the Veterans Health Administration

Arthritis Care &Research, EarlyView.
Objective Though used frequently to treat flare, risk of long‐term opioid exposure in gout has not been well defined. In this study, we examined the hypothesis that people with gout are more likely than individuals without gout to be prescribed long‐term opioids over time.
Lindsay N. Helget, Bryant R. England, Punyasha Roul, Harlan Sayles, Tuhina Neogi, James R. O'Dell, Joshua F. Baker, Ted R. Mikuls   +7 more
wiley   +1 more source

An ‘alcohol health champions’ intervention to reduce alcohol harm in local communities: a mixed-methods evaluation of a natural experiment

Public Health Research
Background Globally alcohol consumption is a leading risk factor for premature death and disability and is associated with crime, social and economic consequences. Local communities may be able to play a role in addressing alcohol-related issues in their
Elizabeth J Burns, Frank de Vocht, Noemia Siqueira, Cathy Ure, Suzanne Audrey, Margaret Coffey, Susan Hare, Suzy C Hargreaves, Mira Hidajat, Steve Parrott, Lauren Scott, Penny A Cook   +11 more
doaj   +1 more source

Diabetic Ketoacidosis (DKA) Insulin Infusion Protocol Update Using Evidence-Based Practice: A Quality Improvement Project [PDF]

, 2018
Diabetic Ketoacidosis is a life-threatening side effect to Diabetes Mellitus. Standards of treatment and recommendations are made by the American Diabetes Association.
Lacey, Susan K
core   +1 more source