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Stepped Wedge Cluster Randomized Trials: A Methodological Overview
World Neurosurgery, 2022Stepped wedge cluster randomized trials enable rigorous evaluations of health intervention programs in pragmatic settings. In the present study, we aimed to update neurosurgeon scientists on the design of stepped wedge randomized trials.We have presented an overview of recent methodological developments for stepped wedge designs and included an update ...
Fan Li, Rui Wang
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Bayesian optimal stepped wedge design
Biometrical Journal, 2023AbstractRecently, there has been a growing interest in designing cluster trials using stepped wedge design (SWD). An SWD is a type of cluster–crossover design in which clusters of individuals are randomized unidirectional from a control to an intervention at certain time points.
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Statistics & Probability Letters, 2015
Stepped wedge randomised trials are increasingly popular. Here we derive the optimal design for a fixed number of periods; this does not allocate an equal number of cluster units to each treatment sequence as might otherwise have been expected.
Jock Lawrie +2 more
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Stepped wedge randomised trials are increasingly popular. Here we derive the optimal design for a fixed number of periods; this does not allocate an equal number of cluster units to each treatment sequence as might otherwise have been expected.
Jock Lawrie +2 more
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Power analysis for stepped wedge trials with multiple interventions
Statistics in Medicine, 2022Stepped wedge design (SWD) trials are cluster randomized trials that feature staggered, unidirectional cross‐over between treatment conditions. Existing literature on power for SWDs focuses primarily on designs with two conditions, typically a control and an intervention condition. However, SWDs with more than one treatment condition are being proposed
Phillip Sundin, Catherine M. Crespi
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Variance formulae for multiphase stepped wedge cluster randomized trial
Statistics in Medicine, 2020AbstractIn a multiphase stepped wedge cluster randomized trial (MSW‐CRT), more than one intervention will be initiated on each sequence in a fixed order. Hence, with the MSW‐CRT design, the effect of the first intervention can be evaluated when compared to control, as well as the added‐on effects of the subsequent interventions.
Pengyue Zhang +3 more
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Design and analysis of stepped wedge cluster randomized trials
Contemporary Clinical Trials, 2007Cluster randomized trials (CRT) are often used to evaluate therapies or interventions in situations where individual randomization is not possible or not desirable for logistic, financial or ethical reasons. While a significant and rapidly growing body of literature exists on CRTs utilizing a "parallel" design (i.e.
Michael A, Hussey, James P, Hughes
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TVZ - Verpleegkunde in praktijk en wetenschap, 2021
Janneke de Man-Van Ginkel, Roelof Ettema
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Janneke de Man-Van Ginkel, Roelof Ettema
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Information Content of Cluster–Period Cells in Stepped Wedge Trials
Biometrics, 2018Summary Stepped wedge and other multiple-period cluster randomized trials, which collect data from multiple clusters across multiple time periods, are being conducted with increasing frequency; statistical research into these designs has not kept apace.
Jessica Kasza, Andrew B. Forbes
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Step-wedge spectrometer for pulsed X-ray sources
The 31st IEEE International Conference on Plasma Science, 2004. ICOPS 2004. IEEE Conference Record - Abstracts., 2004Summary form only given. High-current (/spl sim/10 kA), pulsed (/spl sim/25 ns), bremsstrahlung X-ray sources in the 100 keV to 2 MeV regime are commonly used to radiograph hydrodynamic physics experiments. Knowledge of the spectrum is useful both in improving source performance and image analysis.
F.J. Goldin, M. Aufderheide
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Nederlands tijdschrift voor geneeskunde, 2012
Not all questions concerning therapeutic effects in medical research can be answered satisfactorily by standard trials. The stepped wedge cluster design is a special form of randomised study in which an intervention at group level is implemented in stages. The design can be used in situations where randomization at the patient level is inappropriate or
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Not all questions concerning therapeutic effects in medical research can be answered satisfactorily by standard trials. The stepped wedge cluster design is a special form of randomised study in which an intervention at group level is implemented in stages. The design can be used in situations where randomization at the patient level is inappropriate or
openaire +1 more source