Results 21 to 30 of about 19,338 (286)

Five questions to consider before conducting a stepped wedge trial. [PDF]

, 2015
Researchers should consider five questions before starting a stepped wedge trial. Why are you planning one? Researchers sometimes think that stepped wedge trials are useful when there is little doubt about the benefit of the intervention being tested ...
Baio, G, Beard, E, Copas, AJ, Davey, C, Fielding, KL, Hargreaves, JR, Lewis, JJ, Osrin, D, Prost, A, Thompson, JA   +9 more
core   +4 more sources

Divergent confidence intervals among pre-specified analyses in the HiSTORIC stepped wedge trial: An exploratory post-hoc investigation.

PLoS ONE, 2022
BackgroundThe high-sensitivity cardiac troponin on presentation to rule out myocardial infarction (HiSTORIC) study was a stepped-wedge cluster randomised trial with long before-and-after periods, involving seven hospitals across Scotland.
Richard A Parker, Catriona Keerie, Christopher J Weir, Atul Anand, Nicholas L Mills   +4 more
doaj   +1 more source

The optimal design of stepped wedge trials with equal allocation to sequences and a comparison to other trial designs. [PDF]

, 2017
Background/Aims We sought to optimise the design of stepped wedge trials with an equal allocation of clusters to sequences and explored sample size comparisons with alternative trial designs.
Copas, Andrew, Fielding, Katherine, Hargreaves, James, Thompson, Jennifer A   +3 more
core   +2 more sources

Community participatory learning and action cycle groups to reduce type 2 diabetes in Bangladesh (D:Clare): an updated study protocol for a parallel arm cluster randomised controlled trial

Trials, 2023
The “Diabetes: Community-led Awareness, Response and Evaluation” (D:Clare) trial aims to scale up and replicate an evidence-based participatory learning and action cycle intervention in Bangladesh, to inform policy on population-level T2DM prevention and
Carina King, Malini Pires, Naveed Ahmed, Kohenour Akter, Abdul Kuddus, Andrew Copas, Hassan Haghparast-Bidgoli, Joanna Morrison, Tasmin Nahar, Sanjit Kumer Shaha, AKAzad Khan, Kishwar Azad, Edward Fottrell   +12 more
doaj   +1 more source

A pragmatic, multi-centered, stepped wedge, cluster randomized controlled trial pilot of the clinical and cost effectiveness of a complex Stroke Oral healthCare intervention pLan Evaluation II (SOCLE II) compared with usual oral healthcare in stroke wards [PDF]

, 2019
BACKGROUND: Patients with stroke-associated pneumonia experience poorer outcomes (increased hospital stays, costs, discharge dependency, and risk of death).
Bain, Brenda Jean, Barr, John, Bowers, Naomi, Brady, Marian C., Chalmers, Campbell, Colins, Marissa, Gray, Heather, Keerie, Catriona, Langhorne, Peter, Pollock, Alex, Stott, David J., Sweeney, Petrina, Weir, Christopher J.   +12 more
core   +2 more sources

How important is randomisation in a stepped wedge trial? [PDF]

, 2015
In cluster randomised trials, randomisation increases internal study validity. If enough clusters are randomised, an unadjusted analysis should be unbiased.
Copas, Andrew J, Fielding, Katherine L, Hargreaves, James R, Prost, Audrey   +3 more
core   +1 more source

Improving HPV Vaccination Rates: A Stepped-Wedge Randomized Trial [PDF]

Pediatrics, 2020
OBJECTIVES: To evaluate the effectiveness of a stepped-wedge randomized trial of Development of Systems and Education for Human Papillomavirus Vaccination (DOSE HPV), a multilevel intervention. METHODS:
Rebecca B, Perkins, Aaron, Legler, Emily, Jansen, Judith, Bernstein, Natalie, Pierre-Joseph, Terresa J, Eun, Dea L, Biancarelli, Thomas J, Schuch, Karin, Leschly, Anny T H R, Fenton, William G, Adams, Jack A, Clark, Mari-Lynn, Drainoni, Amresh, Hanchate   +13 more
openaire   +2 more sources

Application of a nonrandomized stepped wedge design to evaluate an evidence-based quality improvement intervention: a proof of concept using simulated data on patient-centered medical homes

BMC Medical Research Methodology, 2016
Background Stepped wedge designs have gained recognition as a method for rigorously assessing implementation of evidence-based quality improvement interventions (QIIs) across multiple healthcare sites.
Alexis K. Huynh, Martin L. Lee, Melissa M. Farmer, Lisa V. Rubenstein   +3 more
doaj   +1 more source

Logistic, ethical, and political dimensions of stepped wedge trials: critical review and case studies [PDF]

, 2015
Background: Three arguments are usually invoked in favour of stepped wedge cluster randomised controlled trials: the logistic convenience of implementing an intervention in phases, the ethical benefit of providing the intervention to all clusters, and ...
Abubakar, Ibrahim, Ayles, Helen, Binik, Ariella, De Allegri, Manuela, Dreischulte, Tobias, Lewis, James J., Mouchoux, Christelle, Osrin, David, Prost, Audrey, Roy, Anjana   +9 more
core   +5 more sources

Experimental investigation of the effect of a step and wedge on the performance of a high-speed craft in calm water and statistical analysis of its seakeeping in irregular waves

AIP Advances, 2020
Analysis of the hydrodynamic performance of a high-speed craft in calm water and seakeeping in irregular waves have attracted the attention of many researchers.
Sayyed Mahdi Sajedi, Parviz Ghadimi
doaj   +1 more source