Robust inference for the stepped wedge design
Biometrics, 2019 AbstractStepped wedge designed trials are a type of cluster‐randomized study in which the intervention is introduced to each cluster in a random order over time. This design is often used to assess the effect of a new intervention as it is rolled out across a series of clinics or communities.
James P. Hughes +3 more
openaire +4 more sources
Sample size considerations for stepped wedge designs with subclusters
Biometrics, 2021 AbstractThe stepped wedge cluster randomized trial (SW‐CRT) is an increasingly popular design for evaluating health service delivery or policy interventions. An essential consideration of this design is the need to account for both within‐period and between‐period correlations in sample size calculations.
Kendra Davis‐Plourde +2 more
openaire +3 more sources
Trials, 2018 Background Quality of cardiopulmonary resuscitation (CPR) is associated with survival, but recommended guidelines are often not met, and less than half the children with an in-hospital arrest will survive to discharge.
Ron W. Reeder +36 more
doaj +1 more source
Developing and evaluating a lay health worker delivered implementation intervention to decrease engagement disparities in behavioural parent training: a mixed methods study protocol. [PDF]
, 2019 IntroductionBehavioural parent training (BPT) programmes are effective in preventing and treating early-onset conduct problems and child maltreatment. Unfortunately, pervasive mental health service disparities continue to limit access to and engagement ...
Barnett, Miya +5 more
core +1 more source
BMC Public Health, 2010 Background Approximately 55,000 children in New Zealand do not eat breakfast on any given day. Regular breakfast skipping has been associated with poor diets, higher body mass index, and adverse effects on children's behaviour and academic performance ...
Maddison Ralph +6 more
doaj +1 more source
Randomised controlled trials of complex interventions and large-scale transformation of services [PDF]
, 2016 Complex interventions and large-scale transformations of services are necessary to meet the health-care challenges of the 21st century. However, the evaluation of these types of interventions is challenging and requires methodological development ...
Barratt, Helen +4 more
core +1 more source
Vaccine trials during a pandemic: potential approaches to ethical dilemmas
Trials, 2021 Ever since the emergence of the coronavirus disease 2019 (COVID-19), global public health infrastructures and systems, along with community-wide collaboration and service, have risen to an unprecedented challenge.
Manaf Alqahtani +3 more
doaj +1 more source
The prevention and reduction of weight loss in an acute tertiary care setting: Protocol for a pragmatic stepped wedge randomised cluster trial (the PRoWL Project) [PDF]
, 2013 Background: Malnutrition, with accompanying weight loss, is an unnecessary risk in hospitalised persons and often remains poorly recognised and managed.
A Dickinson +85 more
core +3 more sources
Response adaptive intervention allocation in stepped‐wedge cluster randomized trials
Statistics in Medicine, 2022 BackgroundStepped‐wedge cluster randomized trial (SW‐CRT) designs are often used when there is a desire to provide an intervention to all enrolled clusters, because of a belief that it will be effective. However, given there should be equipoise at trial commencement, there has been discussion around whether a pre‐trial decision to provide the ...
Grayling, Michael J +2 more
openaire +5 more sources
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source