Results 71 to 80 of about 19,338 (286)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Comparison of analysis methods and design choices for treatment-by-period interaction in unidirectional switch designs: a simulation study

BMC Medical Research Methodology, 2022
Background Due to identifiability problems, statistical inference about treatment-by-period interactions has not been discussed for stepped wedge designs in the literature thus far.
Zhuozhao Zhan, Geertruida H. de Bock, Edwin R. van den Heuvel   +2 more
doaj   +1 more source

Evaluation of multiple interventions using a stepped wedge design [PDF]

, 2017
Background: Stepped wedge cluster randomized trials are a class of unidirectional crossover studies that have historically been limited to evaluating a single intervention.
Hughes, James, Li, Lingyu, Lyons, Vivian H, Rowhani-Rahbar, Ali   +3 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Effect and associated factors of a clinical pharmacy model in the incidence of medication errors (EACPharModel) in the Hospital Pablo Tobón Uribe: study protocol for a stepped wedge randomized controlled trial (NCT03338725)

Trials, 2020
Background According to WHO, medication error (ME) is a subject that requires attention at all levels of care to reduce severe and preventable damage related to medication use.
J. Granados, A. Salazar-Ospina, J. P. Botero-Aguirre, A. F. Valencia-Quintero, N. Ortiz, P. Amariles   +5 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Feasibility of a theory-based intervention to reduce sedentary behaviour among contact centre staff: the SUH stepped-wedge cluster RCT

Public Health Research, 2022
Background: Sedentary behaviour is linked to increased risk of type 2 diabetes, cardiovascular disease, musculoskeletal issues and poor mental well-being.
Ruth Jepson, Graham Baker, Divya Sivaramakrishnan, Jillian Manner, Richard Parker, Scott Lloyd, Andrew Stoddart   +6 more
doaj   +1 more source

Examining evidence based resistance plus balance training in community-dwelling older adults with complex health care needs: Trial protocol for the Muscling Up Against Disability project [PDF]

, 2017
Available online 6 October 2016Abstract not availableJustin W.L.
Gardiner, Paul, Henwood, Tim, Hodgkinson, Brent, Keogh, Justin W L, Rouse, Kevin, Tuckett, Anthony   +5 more
core   +2 more sources

Multilevel Intervention Stepped Wedge Designs (MLI-SWDs)

Prevention Science
AbstractMultilevel interventions (MLIs) hold promise for reducing health inequities by intervening at multiple types of social determinants of health consistent with the socioecological model of health. In spite of their potential, methodological challenges related to study design compounded by a lack of tools for sample size calculation inhibit their ...
Linnan, Laura, Kneipp, Shawn M., Sperger, John, Kosorok, Michael R.   +3 more
openaire   +2 more sources

Permutation tests for stepped-wedge cluster-randomized trials [PDF]

The Stata Journal: Promoting communications on statistics and Stata, 2019
Permutation tests are useful in stepped-wedge trials to provide robust statistical tests of intervention-effect estimates. However, the permute command does not produce valid tests in this setting because individual observations are not exchangeable. We introduce the swpermute command, which permutes clusters to sequences to maintain exchangeability ...
Jennifer Thompson, Calum Davey, Richard Hayes, James Hargreaves, Katherine Fielding   +4 more
openaire   +1 more source