Method and reporting guideline for stepped-wedge trials
Zhongguo gonggong weisheng, 2022 Stepped-wedge trial is an emerging cluster randomized controlled trial in the field of service provision and policy evaluation, which is becoming increasingly popular among health care researchers in recent years.
Hua-xin SI, Xiao-xia QIAO, Ya-ru JIN
doaj +2 more sources
The stepped wedge trial design: a systematic review [PDF]
BMC Medical Research Methodology, 2006 Background Stepped wedge randomised trial designs involve sequential roll-out of an intervention to participants (individuals or clusters) over a number of time periods.
Lilford Richard J, Brown Celia A
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Sample size calculation for a stepped wedge trial. [PDF]
Trials, 2015 BACKGROUND: Stepped wedge trials (SWTs) can be considered as a variant of a clustered randomised trial, although in many ways they embed additional complications from the point of view of statistical design and analysis.
Ambler, Gareth +5 more
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Group sequential designs for stepped-wedge cluster randomised trials. [PDF]
Clinical Trials, 2017 BACKGROUND/AIMS: The stepped-wedge cluster randomised trial design has received substantial attention in recent years. Although various extensions to the original design have been proposed, no guidance is available on the design of stepped-wedge cluster ...
Grayling, Michael J +2 more
core +5 more sources
Improving efficiency in the stepped-wedge trial design via Bayesian modeling with an informative prior for the time effects. [PDF]
Clin Trials, 2021 Background In a cross-sectional stepped-wedge cluster randomized trial comparing usual care to a new intervention, treatment allocation and time are correlated by design because participants enrolled early in the trial predominantly receive usual care ...
Zhan D, Ouyang Y, Xu L, Wong H.
europepmc +2 more sources
Safety and effectiveness of a non-electric infant warmer for hypothermia in Rwanda: A cluster-randomized stepped-wedge trial. [PDF]
EClinicalMedicine, 2021 Background Neonatal hypothermia is a common source of morbidity and mortality in low resource settings. We developed the Dream Warmer, a low cost, re-usable non-electric infant warmer to prevent and treat hypothermia.
Uwamariya J +10 more
europepmc +2 more sources
Divergent confidence intervals among pre-specified analyses in the HiSTORIC stepped wedge trial: An exploratory post-hoc investigation. [PDF]
PLoS One, 2022 BackgroundThe high-sensitivity cardiac troponin on presentation to rule out myocardial infarction (HiSTORIC) study was a stepped-wedge cluster randomised trial with long before-and-after periods, involving seven hospitals across Scotland.
Parker RA +4 more
europepmc +2 more sources
Oxygen systems and quality of care for children with pneumonia, malaria and diarrhoea: Analysis of a stepped-wedge trial in Nigeria. [PDF]
PLoS One, 2021 Objectives To evaluate the effect of improved hospital oxygen systems on quality of care (QOC) for children with severe pneumonia, severe malaria, and diarrhoea with severe dehydration.
Graham HR +9 more
europepmc +2 more sources
Stepped-wedge randomised trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation: study protocol for a randomized controlled trial [PDF]
Trials, 2018 Background Laparoscopic ventral mesh rectopexy (LVMR) is an established treatment for external full-thickness rectal prolapse. However, its clinical efficacy in patients with internal prolapse is uncertain due to the lack of high-quality evidence ...
Ugo Grossi +12 more
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Five questions to consider before conducting a stepped wedge trial. [PDF]
Trials, 2015 Researchers should consider five questions before starting a stepped wedge trial. Why are you planning one? Researchers sometimes think that stepped wedge trials are useful when there is little doubt about the benefit of the intervention being tested ...
Baio, G +9 more
core +9 more sources