Results 81 to 90 of about 29,380 (303)

Ethical Challenges of Randomized Violence Intervention Trials: Examining the SHARE intervention in Rakai, Uganda. [PDF]

, 2016
ObjectiveWe identify complexities encountered, including unanticipated crossover between trial arms and inadequate 'standard of care' violence services, during a cluster randomized trial (CRT) of a community-level intimate partner violence (IPV) and HIV ...
Nalugoda, Fred, Namatovu, Fredinah, Paul, Amy, Ssekubugu, Robert, Wagman, Jennifer A   +4 more
core   +2 more sources

Methodological progress note: Stepped‐wedge cluster randomized trial design

Journal of Hospital Medicine
Hospitalists are often involved in quality and research efforts to improve care delivery in the inpatient setting.1 To assess the effectiveness of these efforts, new healthcare delivery initiatives may be evaluated by comparing clinical outcomes between patients who received the intervention and those who received usual care, which is commonly used as ...
Alina G. Burek, Amanda Ullman, David C. Brousseau   +2 more
openaire   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial

BMC Public Health, 2023
Background Tuberculosis(TB) is among the leading causes of infectious death worldwide. Contact investigation is an evidence-based, World Health Organisation-endorsed intervention for timely TB diagnosis, treatment, and prevention but has not been widely ...
Achilles Katamba, Amanda J Gupta, Patricia Turimumahoro, Emmanuel Ochom, Joseph M Ggita, Suzan Nakasendwa, Leah Nanziri, Johnson Musinguzi, Rachel Hennein, Moorine Sekadde, Colleen Hanrahan, Raymond Byaruhanga, Erez Yoeli, Stavia Turyahabwe, Adithya Cattamanchi, David W Dowdy, Jessica E Haberer, Mari Armstrong-Hough, Noah Kiwanuka, J. Lucian Davis   +19 more
doaj   +1 more source

The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting [PDF]

BMJ, 2015
The stepped wedge cluster randomised trial is a novel research study design that is increasingly being used in the evaluation of service delivery type interventions. The design involves random and sequential crossover of clusters from control to intervention until all clusters are exposed. It is a pragmatic study design which can reconcile the need for
K, Hemming, T P, Haines, P J, Chilton, A J, Girling, R J, Lilford   +4 more
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Can using the functional resonance analysis method, as an intervention, improve patient safety in hospitals?: a stepped wedge design protocol

BMC Health Services Research, 2021
Background Healthcare professionals are sometimes forced to adjust their work to varying conditions leading to discrepancies between hospital protocols and daily practice. We will examine the discrepancies between protocols, ‘Work As Imagined’ (WAI), and
Liselotte M. van Dijk, Meggie D. Meulman, Linda van Eikenhorst, Hanneke Merten, Bernadette C. F. M. Schutijser, Cordula Wagner   +5 more
doaj   +1 more source

Novel methods for the analysis of stepped wedge cluster randomized trials

Statistics in Medicine, 2019
Stepped wedge cluster randomized trials (SW‐CRTs) have become increasingly popular and are used for a variety of interventions and outcomes, often chosen for their feasibility advantages. SW‐CRTs must account for time trends in the outcome because of the staggered rollout of the intervention.
Lee Kennedy‐Shaffer, Victor de Gruttola, Marc Lipsitch   +2 more
openaire   +4 more sources

Hospital-wide Rollout of Antimicrobial Stewardship: A Stepped-Wedge Randomized Trial [PDF]

Clinical Infectious Diseases, 2014
Our objective was to rigorously evaluate the impact of an antimicrobial stewardship audit-and-feedback intervention, via a stepped-wedge randomized trial. An effective intensive care unit (ICU) audit-and-feedback program was rolled out to 6 non-ICU services in a randomized sequence.
Lesley, Palmay, Marion, Elligsen, Sandra A N, Walker, Ruxandra, Pinto, Scott, Walker, Thomas, Einarson, Andrew, Simor, Anita, Rachlis, Samira, Mubareka, Nick, Daneman   +9 more
openaire   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source