Results 61 to 70 of about 44,113 (283)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Sample size and power analysis for stepped wedge cluster randomised trials with binary outcomes

Statistical Theory and Related Fields, 2021
In stepped wedge cluster randomised trials (SW-CRTs), clusters of subjects are randomly assigned to sequences, where they receive a specific order of treatments.
Jijia Wang, Jing Cao, Song Zhang, Chul Ahn   +3 more
doaj   +1 more source

Eating As Treatment (EAT): A Stepped-Wedge, Randomized Controlled Trial of a Health Behavior Change Intervention Provided by Dietitians to Improve Nutrition in Patients With Head and Neck Cancer Undergoing Radiation Therapy (TROG 12.03) [PDF]

, 2019
Purpose: Malnutrition in head and neck cancer (HNC) treatment is common and associated with poorer morbidity and mortality outcomes. This trial aimed to improve nutritional status during radiation therapy (RT) using a novel method of training dietitians ...
Baker, Amanda L., Bauer, Judith, Beck, Alison K., Britton, Ben, Carter, Gregory, Harrowfield, Jane, Isenring, Elizabeth, McCarter, Kristen, Oldmeadow, Chris, Tang, Colin, Wolfenden, Luke, Wratten, Chris   +11 more
core   +1 more source

A Step-Wedge in the Biochemical Diagnosis of Preeclampsia [PDF]

Clinical Chemistry, 2019
Preeclampsia, a hypertensive disorder of pregnancy, is one of the leading causes of maternal and neonatal morbidity and mortality worldwide. Among the reasons for the great global burden of disease is the poor predictive value of high blood pressure and proteinuria (traditional markers for the disease) for related adverse outcomes (1).
Elizabeth R, Lemoine, S Ananth, Karumanchi   +1 more
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Rollout trial designs in implementation research are often necessary and sometimes preferred

Implementation Science
Background Rollout designs, which include stepped wedge designs, are defined by staggered implementation of new or alternative programs or services. Critiques of stepped wedge and other rollout designs have raised concerns regarding the confounding of ...
Gregory E. Simon, Bryan R. Garner, Justin D. Smith, Peter A. Wyman, Theresa E. Matson, Lia Chin-Purcell, Ian Cero, Wouter Vermeer, Kimberly A. Johnson, Guillermo Prado, C. Hendricks Brown   +10 more
doaj   +1 more source

Parable of two agencies, one of which randomizes [PDF]

, 2010
This article examines the design of evaluations in settings where there is a choice as to how an intervention is to be introduced and evaluated. It uses data from a supervision program for offenders on probation in the UK (Bruce and Hollin forthcoming ...
Bowles, R., McDougall, C., Pearson, Dominic, Torgerson, D.   +3 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative symptom control in cancer (E2C2): addendum

Trials, 2023
We previously described the hypotheses, outcomes, design, and analysis for E2C2, a pragmatic stepped-wedge trial to assess an intervention to improve symptom control in patients with cancer.
Jeph Herrin, Lila J. Finney Rutten, Kathryn J. Ruddy, Kurt Kroenke, Andrea L. Cheville   +4 more
doaj   +1 more source