Results 81 to 90 of about 43,887 (283)

Comparison of analysis methods and design choices for treatment-by-period interaction in unidirectional switch designs: a simulation study

BMC Medical Research Methodology, 2022
Background Due to identifiability problems, statistical inference about treatment-by-period interactions has not been discussed for stepped wedge designs in the literature thus far.
Zhuozhao Zhan, Geertruida H. de Bock, Edwin R. van den Heuvel   +2 more
doaj   +1 more source

Ethnolinguistic concordance and the receipt of postpartum IUD counseling services in Sri Lanka. [PDF]

, 2018
CONTEXT: Ethnic and linguistic concordance are important dimensions of the patient-physician relationship, and are linked to health care disparities.
Canning, David, de Silva, Ranjith, Karra, Mahesh, Pearson, Erin, Samarasekera, Arnjali, Shah, Iqbal   +5 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Stepped wedge cluster randomized controlled trials: sample size and power determinations [PDF]

, 2014
Stepped wedge cluster randomized controlled trials (RCTs) are increasingly used in evaluating a causal-effect relationship between an intervention and an outcome. Sample size and power calculations are critical in designing a statistical study. Thus, the
Chen, Hsiang-Yu
core  

Multilevel Intervention Stepped Wedge Designs (MLI-SWDs)

Prevention Science
AbstractMultilevel interventions (MLIs) hold promise for reducing health inequities by intervening at multiple types of social determinants of health consistent with the socioecological model of health. In spite of their potential, methodological challenges related to study design compounded by a lack of tools for sample size calculation inhibit their ...
Linnan, Laura, Kneipp, Shawn M., Sperger, John, Kosorok, Michael R.   +3 more
openaire   +2 more sources

Permutation tests for stepped-wedge cluster-randomized trials [PDF]

The Stata Journal: Promoting communications on statistics and Stata, 2019
Permutation tests are useful in stepped-wedge trials to provide robust statistical tests of intervention-effect estimates. However, the permute command does not produce valid tests in this setting because individual observations are not exchangeable. We introduce the swpermute command, which permutes clusters to sequences to maintain exchangeability ...
Jennifer Thompson, Calum Davey, Richard Hayes, James Hargreaves, Katherine Fielding   +4 more
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Feasibility of a theory-based intervention to reduce sedentary behaviour among contact centre staff: the SUH stepped-wedge cluster RCT

Public Health Research, 2022
Background: Sedentary behaviour is linked to increased risk of type 2 diabetes, cardiovascular disease, musculoskeletal issues and poor mental well-being.
Ruth Jepson, Graham Baker, Divya Sivaramakrishnan, Jillian Manner, Richard Parker, Scott Lloyd, Andrew Stoddart   +6 more
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Comparative evaluation of the stepped wedge design efficiency [PDF]

Trials, 2013
The cluster randomised trial (CRT) design is widely used to evaluate interventions targeted at the cluster level and helps alleviate contamination within clusters. CRTs usually require large sample sizes, although matched pair CRTs can limit this problem.
Baio, Gianluca, Omar, Rumana, Ambler, Gareth   +2 more
openaire   +1 more source