Results 31 to 40 of about 6,729 (263)

GeriMedRisk, a telemedicine geriatric pharmacology consultation service to address adverse drug events in long-term care: a stepped-wedge cluster randomized feasibility trial protocol (ISRCTN17219647)

Pilot and Feasibility Studies, 2018
Background Multimorbidity, polypharmacy, and older age predispose seniors to adverse drug events (ADE). Seniors with an ADE experience greater morbidity, mortality, and health care utilization compared to their younger counterparts.
Joanne Man-Wai Ho, Jennifer Tung, Janine Maitland, Derelie Mangin, Lehana Thabane, J. Michael Pavlin, Jeffrey Alfonsi, Anne Holbrook, Sharon Straus, Sophiya Benjamin   +9 more
doaj   +1 more source

Major influencing factors on routine implementation of shared decision-making in cancer care: qualitative process evaluation of a stepped-wedge cluster randomized trial

BMC Health Services Research, 2023
Background Shared decision-making (SDM) is highly relevant in oncology but rarely implemented in routine care. In a stepped-wedge cluster randomized implementation trial, the outcome evaluation of a theoretically and empirically based multi-component SDM
Pola Hahlweg, Anja Lindig, Wiebke Frerichs, Jördis Zill, Henning Hanken, Volkmar Müller, Mia-Carlotta Peters, Isabelle Scholl   +7 more
doaj   +1 more source

Point-of-care ultrasound-guided regional anaesthesia in older ED patients with hip fractures: a study to test the feasibility of a training programme and time needed to complete nerve blocks by ED physicians after training

BMJ Open, 2021
Objectives Point-of-care ultrasound-guided regional anaesthesia (POCUS-GRA) provides safe, rapid analgesia for older people with hip fractures but is rarely performed in the emergency department (ED).
Debra Eagles, Eddy Lang, Marcel Émond, Alex Kiss, Shelley L McLeod, Jordan Chenkin, Bjug Borgundvaag, Andrew D McRae, Jacques Simon Lee, Tina Bhandari, Robert Simard, Claude Topping, Michael Woo, Jeffrey Perry, Charles Wong, Marco Sivilotti, Joseph Newbigging, Donald Melady, Lan Chernoff   +18 more
doaj   +1 more source

Stepped-wedge randomised trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation: study protocol for a randomized controlled trial

Trials, 2018
Background Laparoscopic ventral mesh rectopexy (LVMR) is an established treatment for external full-thickness rectal prolapse. However, its clinical efficacy in patients with internal prolapse is uncertain due to the lack of high-quality evidence ...
Ugo Grossi, Natasha Stevens, Eleanor McAlees, Jon Lacy-Colson, Steven Brown, Anthony Dixon, Gian Luca Di Tanna, S. Mark Scott, Christine Norton, Nadine Marlin, James Mason, Charles H. Knowles, On behalf of the NIHR CapaCiTY working group   +12 more
doaj   +1 more source

Implementation of an evidence-based management algorithm for patients with chronic pancreatitis (COMBO trial): study protocol for a stepped-wedge cluster-randomized controlled trial

Trials, 2023
Background Chronic pancreatitis (CP) is an inflammatory disease that may be complicated by abdominal pain, pancreatic dysfunction, nutritional deficiencies, and diminished bone density.
Florence E. M. de Rijk, Charlotte L. van Veldhuisen, Marc G. Besselink, Jeanin E. van Hooft, Hjalmar C. van Santvoort, Erwin J. M. van Geenen, Cornelis H. van Werkhoven, Pieter Jan F. de Jonge, Marco J. Bruno, Robert C. Verdonk, for the Dutch Pancreatitis Study Group   +10 more
doaj   +1 more source

Stepped-wedge cluster randomised trials: where, when and why? [PDF]

Trials, 2015
The stepped wedge (SW) cluster randomised trial (CRT) design is being utilised at increasing pace. However, little is known about the standard of reporting of such trials, or how useful the design has proven to be in hindsight. Moreover, much debate exists around when the design should be preferred to the more classical parallel group (PG) CRT.
Grayling, Michael, Wason, James, Mander, Adrian   +2 more
openaire   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A website for cluster randomised trials including stepped wedge: facilitating quality trials and methodological research

Trials
Background A cluster randomised trial is a randomised controlled trial in which groups of individuals (clusters) are randomised to treatment arms.
Claire L. Chan, Clémence Leyrat, James Martin, Jennifer Thompson, Elizabeth L. Turner, Sandra M. Eldridge   +5 more
doaj   +1 more source

阶梯整群随机试验 Stepped Wedge Cluster Randomized Trials

Zhongguo cuzhong zazhi, 2023
阶梯整群随机试验（stepped wedge cluster randomized trial，SW-CRT）是一种新型的研究设计，通常用于评价整群的服务或政策干预效果。该设计不需要单独设立对照，在设计初始阶段，所有整群均不暴露于干预，随后每一个观察期随机一组整群接受干预，进入干预组，直到所有整群均接受干预。本文从SW-CRT的基本原理、类别、研究设计、样本量计算、统计学方法和报告规范等方面进行介绍，为开展SW-CRT研究提供参考。 Abstract: The stepped wedge ...
王孟, 王春娟, 李子孝, 谷鸿秋
doaj   +1 more source

How important is randomisation in a stepped wedge trial? [PDF]

Trials, 2015
In cluster randomised trials, randomisation increases internal study validity. If enough clusters are randomised, an unadjusted analysis should be unbiased. If a smaller number of clusters are included, stratified or matched randomisation can increase comparability between trial arms.
Hargreaves, James R, Prost, Audrey, Fielding, Katherine L, Copas, Andrew J   +3 more
openaire   +3 more sources