Results 31 to 40 of about 90,354 (334)

Novel Ordered Stepped-Wedge Cluster Trial Designs for Detecting Ebola Vaccine Efficacy Using a Spatially Structured Mathematical Model. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:During the 2014 Ebola virus disease (EVD) outbreak, policy-makers were confronted with difficult decisions on how best to test the efficacy of EVD vaccines.
Ibrahim Diakite, Eric Q Mooring, Gustavo E Velásquez, Megan B Murray   +3 more
doaj   +1 more source

Implementation of patient-reported outcomes for symptom management in oncology practice through the SIMPRO research consortium: a protocol for a pragmatic type II hybrid effectiveness-implementation multi-center cluster-randomized stepped wedge trial

Trials, 2022
Background Many cancer patients experience high symptom burden. Healthcare in the USA is reactive, not proactive, and doctor-patient communication is often suboptimal. As a result, symptomatic patients may suffer between clinic visits.
M. Hassett, S. Wong, R. Osarogiagbon, Jessica J Bian, D. Dizon, H. H. Jenkins, H. Uno, Christine M Cronin, D. Schrag   +8 more
semanticscholar   +1 more source

Design, rationale and analysis plan for the Stand Up for Health trial in contact centres: a stepped wedge feasibility study

Pilot and Feasibility Studies, 2020
Background Contact centres are one of the most sedentary workplaces, with employees spending a very high proportion of their working day sitting down.
Richard A. Parker, Jillian Manner, Divya Sivaramakrishnan, Graham Baker, Andrew Stoddart, Scott Lloyd, Ruth Jepson   +6 more
doaj   +1 more source

A cluster randomized stepped-wedge trial to de-implement unnecessary post-operative antibiotics in children: the optimizing perioperative antibiotic in children (OPerAtiC) trial

Implementation Science, 2021
Background Antibiotic-resistant infections have become a public health crisis that is driven by the inappropriate use of antibiotics. In the USA, antibiotic stewardship programs (ASP) have been established and are required by regulatory agencies to help ...
S. Malone, V. Mckay, Christina Krucylak, B. Powell, Jingxia Liu, Cindy M Terrill, Jacqueline M. Saito, S. Rangel, J. Newland   +8 more
semanticscholar   +1 more source

Impact of a Geriatric Intervention to Improve Screening and Management of Undernutrition in Older Patients Undergoing Surgery for Colorectal Cancer: Results of the ANC Stepped-Wedge Trial

Nutrients, 2021
Almost two in three patients who are aged 75 years and older and scheduled for surgery for colorectal cancer (CRC) are undernourished. Despite evidence that perioperative nutritional management can improve patients outcomes, international guidelines are ...
Thomas Gilbert, L. Bernard, Marine Alexandre, Sylvie Bin-Dorel, L. Villeneuve, E. Decullier, M. Bonnefoy, Anc Working Group   +7 more
semanticscholar   +1 more source

Community participatory learning and action cycle groups to reduce type 2 diabetes in Bangladesh (D:Clare): an updated study protocol for a parallel arm cluster randomised controlled trial

Trials, 2023
The “Diabetes: Community-led Awareness, Response and Evaluation” (D:Clare) trial aims to scale up and replicate an evidence-based participatory learning and action cycle intervention in Bangladesh, to inform policy on population-level T2DM prevention and
Carina King, Malini Pires, Naveed Ahmed, Kohenour Akter, Abdul Kuddus, Andrew Copas, Hassan Haghparast-Bidgoli, Joanna Morrison, Tasmin Nahar, Sanjit Kumer Shaha, AKAzad Khan, Kishwar Azad, Edward Fottrell   +12 more
doaj   +1 more source

Handoff improvement and adverse event reduction programme implementation in paediatric intensive care units in Argentina: a stepped-wedge trial

BMJ Quality & Safety, 2021
Background There are only a few studies on handoff quality and adverse events (AEs) rigorously evaluating handoff improvement programmes’ effectiveness. None of them have been conducted in low and middle-income countries.
F. Jorro-Barón, I. Suárez-Anzorena, R. Burgos-Pratx, Noelia De Maio, Matías Penazzi, A. P. Rodríguez, G. Rodriguez, D. Velardez, L. Gibbons, Silvina Ábalos, Silvina Lardone, Rosario Gallagher, J. Olivieri, Rocio Rodriguez, J. Vassallo, L. Landry, Ezequiel García-Elorrio   +16 more
semanticscholar   +1 more source

The batched stepped wedge design: A design robust to delays in cluster recruitment [PDF]

, 2022
Stepped wedge designs are an increasingly popular variant of longitudinal cluster randomized trial designs, and roll out interventions across clusters in a randomized, but step‐wise fashion. In the standard stepped wedge design, assumptions regarding the
Bowden, R, Forbes, AB, Hooper, R, Kasza, J   +3 more
core   +1 more source

Can patient decision aids reduce decisional conflict in a de-escalation of breast radiotherapy clinical trial? The PRIMETIME Study Within a Trial implemented using a cluster stepped-wedge trial design

Trials, 2021
Background For patients with early breast cancer considered at very-low risk of local relapse, risks of radiotherapy may outweigh the benefits. Decisions regarding treatment omission can lead to patient uncertainty (decisional conflict), which may be ...
I. Bhattacharya, J. Haviland, L. Turner, H. Stobart, Ada Balasopoulou, L. Stones, A. Kirby, C. Kirwan, C. Coles, Judith M. Bliss   +9 more
semanticscholar   +1 more source

Response adaptive intervention allocation in stepped‐wedge cluster randomized trials

Statistics in Medicine, 2022
BackgroundStepped‐wedge cluster randomized trial (SW‐CRT) designs are often used when there is a desire to provide an intervention to all enrolled clusters, because of a belief that it will be effective. However, given there should be equipoise at trial commencement, there has been discussion around whether a pre‐trial decision to provide the ...
Grayling, Michael J, Wason, James MS, Villar, Sofía S   +2 more
openaire   +5 more sources