Results 51 to 60 of about 90,354 (334)

Permutation tests for stepped-wedge cluster-randomized trials [PDF]

The Stata Journal: Promoting communications on statistics and Stata, 2019
Permutation tests are useful in stepped-wedge trials to provide robust statistical tests of intervention-effect estimates. However, the permute command does not produce valid tests in this setting because individual observations are not exchangeable. We introduce the swpermute command, which permutes clusters to sequences to maintain exchangeability ...
Jennifer Thompson, Calum Davey, Richard Hayes, James Hargreaves, Katherine Fielding   +4 more
openaire   +1 more source

The impact of varying cluster size in cross-sectional stepped-wedge cluster randomised trials

BMC Medical Research Methodology, 2019
Background Cluster randomised trials with unequal sized clusters often have lower precision than with clusters of equal size. To allow for this, sample sizes are inflated by a modified version of the design effect for clustering.
James Thomas Martin, Karla Hemming, Alan Girling   +2 more
doaj   +1 more source

Logistic, ethical, and political dimensions of stepped wedge trials: critical review and case studies [PDF]

, 2015
Background: Three arguments are usually invoked in favour of stepped wedge cluster randomised controlled trials: the logistic convenience of implementing an intervention in phases, the ethical benefit of providing the intervention to all clusters, and ...
Abubakar, Ibrahim, Ayles, Helen, Binik, Ariella, De Allegri, Manuela, Dreischulte, Tobias, Lewis, James J., Mouchoux, Christelle, Osrin, David, Prost, Audrey, Roy, Anjana   +9 more
core   +5 more sources

Effects of a free school breakfast programme on school attendance, achievement, psychosocial function, and nutrition: a stepped wedge cluster randomised trial

BMC Public Health, 2010
Background Approximately 55,000 children in New Zealand do not eat breakfast on any given day. Regular breakfast skipping has been associated with poor diets, higher body mass index, and adverse effects on children's behaviour and academic performance ...
Maddison Ralph, Michie Jo, Jiang Yannan, Gorton Delvina, Turley Maria, Ni Mhurchu Cliona, Hattie John   +6 more
doaj   +1 more source

Evaluating the performance of Bayesian and restricted maximum likelihood estimation for stepped wedge cluster randomized trials with a small number of clusters

BMC Medical Research Methodology, 2022
Background Stepped wedge trials are an appealing and potentially powerful cluster randomized trial design. However, they are frequently implemented with a small number of clusters.
Kelsey L. Grantham, Jessica Kasza, Stephane Heritier, John B. Carlin, Andrew B. Forbes   +4 more
doaj   +1 more source

Impact of early initiation versus national standard of care of antiretroviral therapy in Swaziland's public sector health system : study protocol for a stepped-wedge randomized trial [PDF]

, 2017
Background: There is robust clinical evidence to support offering early access to antiretroviral treatment (ART) to all HIV-positive individuals, irrespective of disease stage, to both improve patient health outcomes and reduce HIV incidence. However, as
Barnighausen, Till, Delva, Wim, Fleming, Yvette, Khumalo, Gavin, Lejeune, Charlotte L, Mazibuko, Sikhathele, Mlambo, Charmaine Khudzie, Okello, Velephi, Reis, Ria, Spiegelman, Donna, Walsh, Fiona J, Zwane, Mandisa   +11 more
core   +5 more sources

Influence of cluster‐period cells in stepped wedge cluster randomized trials

Biometrical Journal, 2022
AbstractStepped wedge cluster randomized trials (SWCRT) are increasingly used for the evaluation of complex interventions in health services research. They randomly allocate treatments to clusters that switch to intervention under investigation at variable time points without returning to control condition. The resulting unbalanced allocation over time
Philipp Mildenberger, Jochem König
openaire   +4 more sources

Co-creation using crowdsourcing to promote PrEP adherence in China: study protocol for a stepped-wedge randomized controlled trial

BMC Public Health, 2022
Background Adherent pre-exposure prophylaxis (PrEP) uptake can prevent HIV infections. Despite the high HIV incidence, Chinese key populations have low PrEP uptake and adherence.
Yongjie Sha, Chunyan Li, Yuan Xiong, Aniruddha Hazra, Jonathan Lio, Ivy Jiang, Haojie Huang, Jared Kerman, Jannelle Molina, Linghua Li, Ke Liang, Dandan Gong, Quanmin Li, Songjie Wu, Renslow Sherer, Joseph D. Tucker, Weiming Tang   +16 more
doaj   +1 more source

Design of trials for interrupting the transmission of endemic pathogens [PDF]

, 2016
Many interventions against infectious diseases have geographically diffuse effects. This leads to contamination between arms in cluster-randomized trials (CRTs).
Hiscox, Alexandra, Homan, Tobias, Maire, Nicolas, Mukabana, Richard, Silkey, Mariabeth, Smith, Thomas A., Takken, Willem   +6 more
core   +3 more sources

Improving outcomes after pediatric cardiac arrest – the ICU-Resuscitation Project: study protocol for a randomized controlled trial

Trials, 2018
Background Quality of cardiopulmonary resuscitation (CPR) is associated with survival, but recommended guidelines are often not met, and less than half the children with an in-hospital arrest will survive to discharge.
Ron W. Reeder, Alan Girling, Heather Wolfe, Richard Holubkov, Robert A. Berg, Maryam Y. Naim, Kathleen L. Meert, Bradley Tilford, Joseph A. Carcillo, Melinda Hamilton, Matthew Bochkoris, Mark Hall, Tensing Maa, Andrew R. Yates, Anil Sapru, Robert Kelly, Myke Federman, J. Michael Dean, Patrick S. McQuillen, Deborah Franzon, Murray M. Pollack, Ashley Siems, John Diddle, David L. Wessel, Peter M. Mourani, Carleen Zebuhr, Robert Bishop, Stuart Friess, Candice Burns, Shirley Viteri, David A. Hehir, R. Whitney Coleman, Tammara L. Jenkins, Daniel A. Notterman, Robert F. Tamburro, Robert M. Sutton, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN)   +36 more
doaj   +1 more source