Results 81 to 90 of about 90,354 (334)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A website for cluster randomised trials including stepped wedge: facilitating quality trials and methodological research

Trials
Background A cluster randomised trial is a randomised controlled trial in which groups of individuals (clusters) are randomised to treatment arms.
Claire L. Chan, Clémence Leyrat, James Martin, Jennifer Thompson, Elizabeth L. Turner, Sandra M. Eldridge   +5 more
doaj   +1 more source

PrEP uptake and HIV viral suppression when PrEP is integrated into Ugandan ART clinics for HIV-negative members of HIV-serodifferent couples: A stepped wedge cluster randomized trial

EClinicalMedicine, 2022
Summary: Background: Global scale-up of HIV pre-exposure prophylaxis (PrEP) includes services to HIV-negative people in partnerships with people living with HIV (serodifferent couples).
Renee Heffron, Timothy R. Muwonge, Katherine K. Thomas, Florence Nambi, Lylianne Nakabugo, Joseph Kibuuka, Dorothy Thomas, Erika Feutz, Allison Meisner, Norma C. Ware, Monique A. Wyatt, Jane M. Simoni, Ingrid T. Katz, Herbert Kadama, Jared M. Baeten, Andrew Mujugira, Renee Heffron, (protocol chair), Jared M. Baeten, Jane Simoni, Deborah Donnell, Ruanne Barnabas, Katherine K. Thomas, Dorothy Thomas, Erika Feutz, Cole Grabow, Allison Meisner, Kristin Ciccarelli, Caitlin Scoville, Katrina Ortblad, Andrew Mujugira, Timothy R. Muwonge, Joseph Kibuuka, Lylianne Nakabugo, Florence Nambi, Mai Nakitende, Diego Izizinga, Vicent Kasita, Brenda Kamusiime, Alisaati Nalumansi, Collins Twesige, Grace Kakoola, Charles Brown, Sylvia Namanda, Herbert Kadama, Norma C. Ware, Monique A. Wyatt, Emily Pisarski, Ingrid T. Katz   +47 more
doaj   +1 more source

Eating As Treatment (EAT): A Stepped-Wedge, Randomized Controlled Trial of a Health Behavior Change Intervention Provided by Dietitians to Improve Nutrition in Patients With Head and Neck Cancer Undergoing Radiation Therapy (TROG 12.03) [PDF]

, 2019
Purpose: Malnutrition in head and neck cancer (HNC) treatment is common and associated with poorer morbidity and mortality outcomes. This trial aimed to improve nutritional status during radiation therapy (RT) using a novel method of training dietitians ...
Baker, Amanda L., Bauer, Judith, Beck, Alison K., Britton, Ben, Carter, Gregory, Harrowfield, Jane, Isenring, Elizabeth, McCarter, Kristen, Oldmeadow, Chris, Tang, Colin, Wolfenden, Luke, Wratten, Chris   +11 more
core   +1 more source

Evaluation of the impact of an augmented model of The Productive Ward: Releasing Time to Care on staff and patient outcomes: a naturalistic stepped-wedge trial

BMJ Quality & Safety, 2020
Background Improving the quality and efficiency of healthcare is an international priority. A range of complex ward based quality initiatives have been developed over recent years, perhaps the most influential programme has been Productive Ward ...
B. Williams, C. Hibberd, D. Baldie, E. Duncan, A. Elders, M. Maxwell, J. Rattray, J. Cowie, H. Strachan, Martyn C. Jones   +9 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

RACE-IT – Rapid Acute Coronary Syndrome Exclusion using the Beckman Coulter Access high-sensitivity cardiac troponin I: A stepped-wedge cluster randomized trial

Contemporary Clinical Trials Communications, 2021
Background: Protocols utilizing high-sensitivity cardiac troponin (hs-cTn) assays for the evaluation of suspected acute coronary syndrome (ACS) in the emergency department (ED) have been gaining popularity across the US and the world.
Joseph Miller, Bernard Cook, Gulmohar Singh-Kucukarslan, Amy Tang, Shooshan Danagoulian, Gerard Heath, Ziad Khalifa, Phillip Levy, Simon A. Mahler, Nicholas Mills, James McCord   +10 more
doaj   +1 more source

Health Economic Evaluation Alongside Stepped Wedge Trials: A Methodological Systematic Review [PDF]

PharmacoEconomics, 2020
Recently, there has been an increase in use of the stepped wedge trial (SWT) design in the context of health services research, due to its pragmatic and methodological advantages over the parallel group design.Our objective was to summarise the statistical methods used when conducting economic evaluations alongside SWTs.A systematic literature search ...
Thomas Lung, Lei Si, Richard Hooper, Gian Luca Di Tanna   +3 more
openaire   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Vaccine trials during a pandemic: potential approaches to ethical dilemmas

Trials, 2021
Ever since the emergence of the coronavirus disease 2019 (COVID-19), global public health infrastructures and systems, along with community-wide collaboration and service, have risen to an unprecedented challenge.
Manaf Alqahtani, Saad I. Mallah, Nigel Stevenson, Sally Doherty   +3 more
doaj   +1 more source