Results 271 to 280 of about 4,595,489 (342)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

One-Year Trajectory of Step Counts and Weight Loss in Adults With Overweight/Obesity: Retrospective Cohort Study. [PDF]

JMIR Mhealth Uhealth
Taguchi K, Oyama A, Kotoku J, Toki H, Yamamoto R.   +4 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Smartphone Step Data for Public Health: Insights From Surveillance in Japan and Future Perspectives. [PDF]

J Epidemiol
Nakagata T, Nakata Y.
europepmc   +1 more source

Revisiting the Technical Steps of the Double-Kissing Crush Technique in a Complicated Case of Left Main Bifurcation. [PDF]

JACC Case Rep
Bedir AŞ, Bedir FF, Gökçe K, Güner A, Uzun F.   +4 more
europepmc   +1 more source

Moiré artifact reduction in grating interferometry using multiple harmonics and total variation regularization. [PDF]

Sci Rep
Meyer HC, Dey J, Dooley CB, Taqi MS, Gala VR, Morrison CD, Fontenot VL, Ham K, Butler LG, Noël A.   +9 more
europepmc   +1 more source

Coordinated alternative splicing decisions via stepwise exon definition. [PDF]

Nucleic Acids Res
Kristofori P, Xiao Z, Braun S, Busch A, Zarnack K, König J, Legewie S, Li C.   +7 more
europepmc   +1 more source

How Adherence to an Evidence-Based Targeted Intervention Procedure is Related to Intervention Effectiveness? [PDF]

Prev Sci
Johander E, Laninga-Wijnen L, Graf D, Chávez DV, Salmivalli C.   +4 more
europepmc   +1 more source

Step count recovery patterns in the first six weeks after knee replacement in individuals with knee osteoarthritis: a secondary analysis of a prospective observational cohort study using wrist-worn accelerometry. [PDF]

Rheumatol Int
Olanrewaju AE, Pritchard E, Shao S, Price AJ, Doherty A, van der Veer SN, Wong DC, Small SR, Filbay SR, Dixon WG.   +9 more
europepmc   +1 more source