Results 181 to 190 of about 52,263 (284)

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

Multicenter evaluation of planning quality in intracranial stereotactic radiotherapy for brain metastases. [PDF]

Phys Imaging Radiat Oncol
Abdollahi S, Boucenna R, Chatelain C, Corradini N, Fargier-Voiron M, Fave V, Garcia J, Ghandour S, Guckenberger M, Haller K, Härtig M, Hertel T, Jaccard M, Klöck S, Krayenbühl J, López NR, Logaritsch P, Pemler P, Petermann H, Pisaturo O, Pupillo F, Schmidhalter D, Tata C, Thengumpallil S, Vallet V, Weber P, Andratschke N, Tanadini-Lang S.   +27 more
europepmc   +1 more source

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source

Volumetric and Linear Imaging Response After Stereotactic Radiotherapy for Vestibular Schwannoma. [PDF]

Cureus
Rocha EM, Costa PT, Arantes M, Aguiar A, Pires A, Conde S.   +5 more
europepmc   +1 more source

Evaluating the role of plan complexity metrics in online adaptive radiotherapy for pancreatic cancer patients

Medical Physics, Volume 53, Issue 6, June 2026.
Abstract Purpose To systematically investigate the behavior of plan complexity metrics (PCMs) in an MR‐Linac online adaptive radiotherapy (oART) workflow for pancreatic cancer, and to evaluate their potential as surrogate indicators of delivery accuracy. Methods Thirty‐seven patients with locally advanced pancreatic cancer were retrospectively analyzed,
Samuele Cavinato, Matteo Galetto, Alessandro Scaggion, Andrea Bettinelli, Matteo Nardini, Giuditta Chiloiro, Angela Romano, Marta Paiusco, Luca Boldrini, Lorenzo Placidi   +9 more
wiley   +1 more source

Modeling dose to normal brain following hypofractionated stereotactic radiotherapy to a single brain metastasis. [PDF]

J Appl Clin Med Phys
Johns E, Hargrave C, Nissen L, Barry TJ, Bernard A, Pinkham MB.   +5 more
europepmc   +1 more source

A Feasibility Study of the Repurposing of Prazosin to Improve Treatment Outcomes in Men Receiving Radiotherapy for Prostate Cancer (MiniRaP‐00)

The Prostate, Volume 86, Issue 8, Page 891-899, June 2026.
ABSTRACT Background Further work is needed to improve treatment outcomes for prostate cancer (PCa), with the repurposing of the α1‐adrenoreceptor antagonists presenting a potential solution. This feasibility clinical trial presents the first prospective data of the use of an α1‐adrenoreceptor antagonist in men undergoing radiotherapy for PCa.
Liam D. King, David Christie, Daniel Cehic, Wendy Dare, Russ Chess‐Williams, Donna Sellers, Catherine McDermott, Alexandra McCarthy, Shailendra Anoopkumar‐Dukie   +8 more
wiley   +1 more source

Harnessing Trace Elements: Novel Radiosensitization Strategies for Enhanced Cancer Radiotherapy

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Radiotherapy (RT) is one of the core methods of comprehensive cancer treatment. Globally, more than 40% of cancer patients rely on radiotherapy to achieve tumor control, cure or palliative relief. However, radiation resistance, immunosuppression and normal tissue injury limit its clinical application.
Yuhuan Zhang, Yizhi Ge, Hongguang Xiang, Ji Liu, Yu Tian, Yan Shen, Dan Zong   +6 more
wiley   +1 more source

Evaluation of the clinical validity of fixation accuracy using an open-face black mask in head stereotactic radiotherapy. [PDF]

Radiol Phys Technol
Takahashi N, Naoi Y, Okano N, Inage Y, Kurokawa C, Shikama N.   +5 more
europepmc   +1 more source

Breast Cancer Multi‐Disciplinary Team Meetings in a Resource‐Constrained System: Are Patients Receiving the Treatment Recommended?

World Journal of Surgery, Volume 50, Issue 6, Page 1481-1486, June 2026.
A total of 556 patients were included in the analyses. Most patients (88%) received primary treatment aligned with the MDT's recommendations. The highest level of concordance was seen in those with early breast cancer who were recommended to have primary surgery (94%), and the lowest in those with metastatic disease.
Nerushka Naidoo, Lindi Martin, Wilhelmina Conradie, Magda Heunis, Charl Petrus Smit, Jenny Edge   +5 more
wiley   +1 more source