Results 191 to 200 of about 168,065 (266)

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Divergent Amplification of Y-Linked Dosage-Sensitive Genes Triggers Regulatory Mismatch Underlying Cattle-Yak Male Sterility. [PDF]

Biomolecules
Wang Y, Chen Y, Zhu Z, Zeng X, Ha W, Su L, Hu L, Liu Y, Li B, Loor J, Jiang M.   +10 more
europepmc   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Maize Anther Development Involves Translated Open Reading Frames From 3' Untranslated Regions. [PDF]

Adv Sci (Weinh)
Wang C, Wu Y, Wang S, Liu H, Jiang S, Han Y, Wu L, Zhang T, Zhang M.   +8 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Redundant Glycerol-3-Phosphate Acyltransferases Regulate Thermo-Sensitive Genic Male Sterility in Rice. [PDF]

Plant Biotechnol J
Cheng S, Zheng H, Tian Y, Wang C, Yu X, Dong K, Wang J, Lu J, Chen K, He X, Shao K, Gao J, Yao B, Hu Y, Xie Z, He L, Xie Z, Zhu Y, Guo S, Lei D, Jian A, Zhu X, Yu H, Zhang S, Chen M, Chen Y, Jiang L, Ren Y, Guo X, Liu S, Liu X, Zhu S, Zhao Z, Wan J.   +33 more
europepmc   +1 more source

Fine mapping and cloning of an intersubspecific reproductive isolation locus <i>MSHB1</i> in rice. [PDF]

Mol Breed
Wang X, Zhang Z, Zhao J, Chen M, Gong J, Han Y, Wei X, Huang X, Fan J.   +8 more
europepmc   +1 more source

Jasmonate regulates male sterility in cucumber. [PDF]

aBIOTECH
Liang H, Liu S, Yan T, Wang H, Li J, Chen H, Yang X, Zhou H, Li S, Yan J.   +9 more
europepmc   +1 more source

Male sterility in Drosophila hybrids revealed by a multi-generational transcriptomic analysis of genes and transposable elements in testes. [PDF]

BMC Biol
Bodelón A, Chillida V, de Oliveira DS, Vieira C, Guerreiro MPG.   +4 more
europepmc   +1 more source

Sterility, safety, and preventive efficacy of three polyvalent hyperimmune sera against bacterial infection in a white mouse challenge model. [PDF]

Front Vet Sci
Tutkyshbay I, Berdikulov M, Yessimsiitova Z, Makhmutov A, Khussainov D, Mussayeva G, Nissanova R, Shynybayev K, Bakiyeva F, Taranov D.   +9 more
europepmc   +1 more source