Results 171 to 180 of about 55,143 (298)

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Scarless Sterilization? A Comparative Study of Vaginal Notes and Laparoscopic Tubal Ligation. [PDF]

Asian J Endosc Surg
Albayrak Denizli AB, Bulutlar E, Boz İzceyhan G, Rol NE, Şahin S.   +4 more
europepmc   +1 more source

Bioengineered Stroma‐Camouflaged Nanovesicles Disrupt the IDO1/CD276 Immunosuppressive Circuit to Reinvigorate Antitumor Immunity

Advanced Science, EarlyView.
Bioengineered stroma‐camouflaged nanovesicles (AM@UIO‐BMS/DOX) convert the immunosuppressive tumor niche into an immunoresponsive milieu by disrupting the IDO1/CD276 circuit. Anti‐CD276 membrane camouflage guides tumor accumulation and deep penetration, enabling controlled co‐delivery of DOX and the IDO1 inhibitor BMS‐986205.
Ziqi Zhang, Jing Luo, Mengdi Zhang, Jingying Zhuang, Yating Zheng, Yang Zhang, Zhihong Huang, Xinhua Lin, Shuzhen Xu, Hong Yao, Gang Liu, Bing Chen   +11 more
wiley   +1 more source

Association between High-Risk Pregnancy History and High-Efficacy Postpartum Contraception Use in North Carolina. [PDF]

Matern Child Health J
Cox-Terry ME, Enright ED, Dogbey GY, Edwards JM.   +3 more
europepmc   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Exploring Undergraduates' Attitudes Toward Sterilization as Contraception in the Northeastern United States: A Brief Report. [PDF]

Perspect Sex Reprod Health
Mock KO, Patel D, Moyer A.
europepmc   +1 more source

Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth

Advanced Science, EarlyView.
An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang, Jingjing Diao, Junhua Ke, Naru Zhao, Yudi Kuang, Yingjun Wang   +5 more
wiley   +1 more source

A cohort study on inflammatory response and coagulation function changes in women with silver clip or silk ligation sterilisation. [PDF]

Ann Med
Wang Y, Li Y, Wang M, Ma Y, Yang J, Zhang L.   +5 more
europepmc   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

When an Intrauterine Pregnancy Is Not Reassuring: Spontaneous Heterotopic Pregnancy With Tubal Rupture. [PDF]

J Med Cases
Stoyanova N, Caiulo R, Popovski N.
europepmc   +1 more source