Results 101 to 110 of about 482,487 (316)

Recurrent cranio-oculo-facial diabetic complication

open access: yesJournal of Family Medicine and Primary Care, 2019
Diabetic cranial neuropathy is one of the important complications of diabetes with up to 10-fold increase in incidence. It usually affects 3rd, 4th, and 6th cranial nerves.
Anupam Dey
doaj   +1 more source

Novel Nongenomic Signaling by Glucocorticoid May Involve Changes to Liver Membrane Order in Rainbow Trout [PDF]

open access: yesarXiv, 2017
Stress-induced glucocorticoid elevation is a highly conserved response among vertebrates. This facilitates stress adaptation and the mode of action involves activation of the intracellular glucocorticoid receptor leading to the modulation of target gene expression. However, this genomic effect is slow acting and, therefore, a role for glucocorticoid in
arxiv  

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

open access: yesAdvanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai   +5 more
wiley   +1 more source

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang   +18 more
wiley   +1 more source

Simultaneous quantification of cholesterol sulfate, androgen sulfates, and progestagen sulfates in human serum by LC-MS/MS[S]

open access: yesJournal of Lipid Research, 2015
Steroids are primarily present in human fluids in their sulfated forms. Profiling of these compounds is important from both diagnostic and physiological points of view.
Alberto Sánchez-Guijo   +4 more
doaj  

Inadvertent steroid injection into the crystalline lens

open access: yesGMS Ophthalmology Cases, 2017
Intravitreal triamcinolone is administered for a wide number of vitreoretinal conditions. Several complications including cataract formation, raised intraocular pressure, and endophthalmitis have been reported following intravitreal injections. We report
Alam, Md. Shahid, Khetan, Vikas
doaj   +1 more source

BERTQA -- Attention on Steroids [PDF]

open access: yesarXiv, 2019
In this work, we extend the Bidirectional Encoder Representations from Transformers (BERT) with an emphasis on directed coattention to obtain an improved F1 performance on the SQUAD2.0 dataset. The Transformer architecture on which BERT is based places hierarchical global attention on the concatenation of the context and query.
arxiv  

Revealing the Transcriptional and Metabolic Characteristics of Sebocytes Based on the Donkey Cell Transcriptome Atlas

open access: yesAdvanced Science, EarlyView.
In this study, a comprehensive single‐cell transcriptome atlas of the Dezhou donkey, encompassing 20 tissues and 275 050 cells, is constructed. Through cross‐species and cross‐tissue analyses, distinct transcriptional patterns in donkey sebocytes are identified.
Yu Tian   +11 more
wiley   +1 more source

Regulatory effect of gut microbes on blood pressure

open access: yesAnimal Models and Experimental Medicine, Volume 5, Issue 6, Page 513-531, December 2022., 2022
The interaction between gut microbiota and hypertension, the genera which affect the blood pressure in taxonomic level, and the commonly used treatments to hypertension based on the gut microbes were summarized in this review. The increases of Lactobacillus, etc.
Dong Yan   +6 more
wiley   +1 more source

A novel deproteinization method from crude polysaccharides of Meretrix meretrix Linnaeus based on palygorskite‐chitosan composite aerogel sieving effect

open access: yeseFood
Due to the delicious taste and remarkable bioactivities of Meretrix meretrix L., they have garnered attention in food field. However, the challenge arises when attempting to separate proteins from crude polysaccharides with similar polarity and ...
Yong Zhu   +7 more
doaj   +1 more source

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