Results 191 to 200 of about 1,020,715 (314)

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, EarlyView.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

Individualized treatment rule for early steroid use in hospitalized patients with community acquired pneumonia: a cohort study. [PDF]

Pneumonia (Nathan)
Odeyemi YE, LeMahieu AM, Barreto EF, Yadav H, Gajic O, Schulte P.   +5 more
europepmc   +1 more source

The role of prenatal maternal sex steroid hormones in weight and adiposity at birth and growth trajectories during infancy [PDF]

Ying Meng, Loralei L. Thornburg, Caitlin Dreisbach, Charlotte Orzolek, Amber Kautz, Hannah R. Murphy, Zorimar Rivera- Núñez, Christina Wang, Richard K. Miller, Thomas G. O’Connor, Emily S. Barrett   +10 more
openalex   +1 more source

Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
It is shown that hepatic c‐Fos responds to feeding, altering de novo lipogenesis, glycolysis, and a wide range of steatosis‐associated metabolic signaling pathways. Obesogenic diets cause hepatic c‐Fos overexpression, insulin resistance, and the induction of metabolic reprogramming‐related genes.
Ao Li, Eduardo H. Gilglioni, Wadsen St‐Pierre‐Wijckmans, Leila Hosseinzadeh, Christelle Veyrat‐Durebex, Sumeet Pal Singh, Roberto Coppari, Latifa Bakiri, Esteban N. Gurzov   +8 more
wiley   +1 more source

Steroid Withdrawal Versus Maintenance in Simultaneous Pancreas-Kidney Transplantation: Long-Term Outcomes in a Single-Center Retrospective Cohort. [PDF]

Clin Transplant
Meier RPH, Abbasi AB, Gamino G, Kelly YM, Tavakol M, Conti G, Sarwal M, Stock PG, Freise CE.   +8 more
europepmc   +1 more source

Vedolizumab–steroid combination therapy improves long-term prognosis in patients with ulcerative colitis [PDF]

Yosuke Yamada, Natsuki Ishida, Tomohiro Takebe, Kenichi Takahashi, Yusuke Asai, Satoshi Tamura, Tomoharu Matsuura, Ryosuke Takano, Ai Matsuura, Mihoko Yamade, Moriya Iwaizumi, Yasushi Hamaya, Takanori Yamada, Satoshi Osawa, Yashiro Yoshizawa, Yoshisuke Hosoda, Yuji Ota, Hiroyuki Hanai, Ken Sugimoto   +18 more
openalex   +1 more source

A Multicenter Validation of a Fully Automated Chemiluminescence Immunoassay for Plasma Elafin in Psoriasis Diagnosis and Severity Assessment

Advanced Science, EarlyView.
The fully automated CLIA demonstrates high sensitivity and specificity for plasma Elafin, achieving 88% diagnostic accuracy and an AUC of 0.92 for psoriasis detection in a multicenter cohort. The assay reliably distinguishes psoriasis from other dermatoses, objectively stratifies disease severity, and allows longitudinal monitoring, supporting its ...
Jingkun Yi, Meng Xu, Ling Han, Zhining Dong, Ruimin Liu, Xiaomei Zhang, Di Hu, Chuanjian Lu, Xiaobo Yu   +8 more
wiley   +1 more source

A Case of Steroid-Dependent Immune Checkpoint Inhibitor Pneumonitis Treated With Subcutaneous Tocilizumab. [PDF]

Respirol Case Rep
Chang N, Meara A, Ho K.
europepmc   +1 more source

Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver

Advanced Science, EarlyView.
This study provides a multi‐omics landscape of treatment‐naïve colorectal liver metastasis and reveals dysregulated molecules and cellular pathways. SHMT1 and NDRG1 Ser330 phosphorylation are demonstrated to display crucial roles in tumorigenesis and liver metastasis. Two proteomics subtypes (metabolism and RNA function) with distinct clinical outcomes
Wensi Zhao, Lei Zhao, Yannan Lian, Zhiwei Liu, Yaqi Li, Xuege Wang, Mingya Zhang, Ni Li, Jingli Guo, Danqing Shen, Shaobo Mo, Jiahao Li, Linhui Zhai, Jiahui Ni, Sangkyu Lee, Bin Liu, Jing Li, Fei Wang, Junjie Peng, Jun Qin, Minjia Tan   +20 more
wiley   +1 more source

High vs. Low Initial Steroid Dose in Autoimmune Pancreatitis: Multicenter Cohort Study on Efficacy and Diabetes Worsening. [PDF]

Diagnostics (Basel)
Iwasa Y, Iwashita T, Iwata K, Tezuka R, Uemura S, Maruta A, Iwata S, Ohashi Y, Yoshida K, Shimizu M.   +9 more
europepmc   +1 more source