Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner [PDF]
17β-Estradiol (E2) attenuates hypoxia-induced pulmonary hypertension (HPH) through estrogen receptor (ER)-dependent effects, including inhibition of hypoxia-induced endothelial cell proliferation; however, the mechanisms responsible for this remain ...
Albrecht, Marjorie+6 more
core +1 more source
Neurogenomic landscape associated with status‐dependent cooperative behaviour
Abstract The neurogenomic mechanisms mediating male–male reproductive cooperative behaviours remain unknown. We leveraged extensive transcriptomic and behavioural data on a neotropical bird species (Pipra filicauda) that performs cooperative courtship displays to understand these mechanisms.
Peri E. Bolton+6 more
wiley +1 more source
Summary Winter dormancy and bud break are crucial to the viability, adaptability and yield of fruit trees, but not all metabolic activities or regulatory factors involved in maintaining and breaking dormancy are known. Here, winter buds, spanning from natural dormancy to bud break, were collected from ‘Cabernet Sauvignon’ grapevines maintained outdoors
Li Chen+5 more
wiley +1 more source
Immunoassays of steroid hormones are still used in the diagnosis and monitoring of patients with congenital adrenal hyperplasia. However, cross-reactivity between steroids can give rise to falsely elevated steroid levels.
Sandra R Dahl+5 more
doaj +1 more source
Occurence of active layer optical properties on some Lasing characteristics dye-doped Ch LC [PDF]
Effect of a planar texture quality and its thickness on lasing spectrums and thresholds in dye-doped cholesteric liquid crystal (CLC) of steroid type is explored. Transition from the qualitative planar texture to the poor texture quality is accompanied by change of characteristic mode structures and by shift of barycentre in the long-wave side and the ...
arxiv
Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202 [PDF]
CYP17A1 is a key steroidogenic enzyme known to conduct several distinct chemical transformations on multiple substrates. In its hydroxylase activity, this enzyme adds a hydroxyl group at the 17α position of both pregnenolone and progesterone at ...
Bangcharoenpaurpong O.+8 more
core +2 more sources
Light Quantity Impacts Early Response to Cold and Cold Acclimation in Young Leaves of Arabidopsis
ABSTRACT Plant reactions to stress vary with development stage and fitness. This study assessed the relationship between light and chilling stress in Arabidopsis acclimation. By analysing the transcriptome and proteome responses of expanding leaves subjected to varying light intensity and cold, 2251 and 2064 early response genes and proteins were ...
Markéta Luklová+14 more
wiley +1 more source
Characterization of a regulatory region of the steroid 21-hydroxylase gene.
Steroid 21-hydroxylase is expressed at high levels in the adrenal gland, where it is required for the synthesis of mineralocorticoids and glucocorticoids. The cis-acting nucleotide sequences required for expression of murine 21-hydroxylase were assessed by stable transfection of Y1 adrenocortical tumor cells with 21-hydroxylase genes containing ...
Bernard P. Schimmer+3 more
openaire +3 more sources
Screening for type 1 diabetes-, thyroid-, gastric-, and adrenal-specific humoral autoimmunity in 529 children and adolescents with celiac disease at diagnosis identifies as positive one in every nine patients [PDF]
No abstract ...
Anania, Caterina+9 more
core +1 more source
Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy
ABSTRACT Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, and metabolic abnormalities.
Yao Shen+5 more
wiley +1 more source