Aqueous solution interactions with sex hormone-binding globulin and estradiol: A theoretical investigation [PDF]
Sex hormone-binding globulin (SHBG) is a binding protein that regulates availability of steroids hormones in the plasma. Although best known as steroid carrier, studies have associated SHBG in modulating behavioral aspects related to sexual receptivity.
arxiv
Unravelling the Origins of Ice Nucleation on Organic Crystals [PDF]
Organic molecules such as steroids or amino acids form crystals that can facilitate the formation of ice -- arguably the most important phase transition on earth. However, the origin of the ice nucleating ability of organic crystals is still largely unknown.
arxiv +1 more source
Extraadrenal immunohistochemical distribution of steroid 21-hydroxylase in human.
Using an antibody against cytochrome P-450 specific for steroid 21-hydroxylase (P-450C21), extraadrenal distribution and localization of the enzyme were immunohistochemically examined on various normal human tissues. Immunoreactive P-450C21 was demonstrated in the renal tubular system, especially in distal tubules and cortical and medullary collecting ...
Hironobu Sasano, Nobuaki Sasano
openaire +4 more sources
Characterisation of neurogenic lipolytic responses in white adipose tissue ex vivo
Background and Purpose Dysfunction of the autonomic nervous system is associated with cardiovascular dysfunction, including metabolic syndrome and obesity. Understanding mechanisms of neurogenic control of white adipose tissue is key to understanding adipose physiology and pathophysiology, though there is limited research exploring this in adipose ...
Kayleigh E. Goddard, Samuel J. Fountain
wiley +1 more source
Remission during pregnancy of severe Chronic Hypertension due to 11-ß Hydroxylase Deficiency [PDF]
When hypertension is a result of an underlying identifiable abnormality, the latter's early discovery can lead to a timely cure of the hypertension and the prevention of its complications.
Attard, Gerhardt, Cachia, Mario J.
core
Apeced in Turkey: a case report and insights on genetic and phenotypic variability [PDF]
APECED is a rare monogenic recessive disorder caused by mutations in the AIRE gene. In this manuscript, we report a male Turkish patient with APECED syndrome who presented with chronic mucocutaneous candidiasis associated with other autoimmune ...
Alessandra Fierabraccia+4 more
core +1 more source
2‐Methoxyestradiol Inhibits the Oxygen‐Sensing Pathway in Keloid Fibroblasts by Targeting HIF‐1α/PHD
ABSTRACT Maintaining oxygen homeostasis is a basic cellular process for adapting to physiological oxygen variations in which the oxygen‐sensing pathway plays a critical role, especially in tumour progression. Little is known about the activity of the oxygen‐sensing pathway in keloid tissue.
Ming‐Zi Zhang+6 more
wiley +1 more source
GCN5‐related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato
Summary The functions of histone acetyltransferases (HATs) in the genetic control of crop traits and the underlying mechanisms are poorly understood. We studied the function of tomato HOOKLESS2 (SlHLS2), a member of the GCN5 family of HATs, through genetic, molecular and genomic approaches. Tomato hls2 mutants generated through CRISPR‐cas9 gene editing
Namrata Jaiswal+3 more
wiley +1 more source
Adrenogenital syndrome: molecular mechanisms of development
On the long multistage pathway of biosynthesis of steroid hormones from cholesterol to cortisol, testosterone and estradiol, due to mutations in genes, there is the deficiency of steroidogenesis enzymes in the adrenal glands: cholesterol desmolase, 3β ...
V.P. Pishak, M.O. Ryznychuk
doaj +1 more source
Stress hormones predict hyperbolic time-discount rates six months later in adults [PDF]
Objectives: Stress hormones have been associated with temporal discounting. Although time-discount rate is shown to be stable over a long term, no study to date examines whether individual differences in stress hormones could predict individuals' time-discount rates in the relatively distant future (e.g., six month later), which is of interest in ...
arxiv