Results 81 to 90 of about 35,670 (271)
Pediatric Rheumatology Online Journal, 2023 Objective To evaluate the impact of anti-tumor necrosis factor-alpha (TNFα: etanercept [Etanercept ®]) therapy on adrenal activity in juvenile idiopathic arthritis (JIA) .
Yonatan Butbul Aviel +4 more
doaj +1 more source
Molecular genetics and epidemiology of steroid 21-hydroxylase deficiency. Origin of disease-causing mutations. [PDF]
, 2002 This thesis is aimed at understanding the relationship between the genetic defects that cause steroid 21-hydroxylase deficiency and the clinical phenotype, and the molecular mechanisms that create these mutations in the CYP21 gene, in a patient ...
Koppens, P.F.J.
core
Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells [PDF]
, 2019 Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus.
Caridis, Anna Maria +4 more
core +1 more source
Andrology, EarlyView.Abstract This is the first episode of a series of four discussions on the differences between males and females, in apparently non‐andrological fields. You will read the transcript of discussions that actually took place at the Endocrinology Unit in Modena, Italy, in the form of the aporetic dialogues of ancient Greece.
Giulia Brigante +7 more
wiley +1 more source
Detrending career statistics in professional baseball: Accounting for the steroids era and beyond [PDF]
Eur. Phys. J. B 79, 67-78 (2011), 2010 There is a long standing debate over how to objectively compare the career achievements of professional athletes from different historical eras. Developing an objective approach will be of particular importance over the next decade as Major League Baseball (MLB) players from the "steroids era" become eligible for Hall of Fame induction. Here we address
arxiv +1 more source
Brain Pathology, EarlyView.We have sought to determine the role that cholesterol metabolism plays in disability worsening and its correlation with progressive MS by analysing patient CSF and post‐mortem tissues using cutting edge mass spectrometry approaches. Key sterol metabolites measured in the CSF link with important disability milestones at the very early stages of MS ...
Lauren Griffiths +13 more
wiley +1 more source
Aldosterone and Dexamethasone Activate African Lungfish Mineralocorticoid Receptor: Increased Activation After Removal of the Amino-Terminal Domain [PDF]
arXiv, 2021 Aldosterone, the main physiological mineralocorticoid in humans and other terrestrial vertebrates, first appears in lungfish, which are lobe-finned fish that are forerunners of terrestrial vertebrates. Aldosterone activation of the MR regulates internal homeostasis of water, sodium and potassium, which was critical in the conquest of land by ...
arxiv
Clinical Endocrinology, EarlyView.ABSTRACT Objective Managing gastrointestinal symptoms in patients with phaeochromocytoma and paraganglioma (PPGL) is challenging due to the risk of catecholaminergic crisis with many commonly prescribed medications, especially in functional tumours.
Monica Majumder +5 more
wiley +1 more source
BMC Medical Genetics, 2010 Background Congenital adrenal hyperplasia due to 21-hydroxylase deficiency is caused by deletions, large gene conversions or mutations in CYP21A2 gene. The human gene is located at 6p21.3 within a locus containing the genes for putative serine/threonine ...
Guerra-Júnior Gil +10 more
doaj +1 more source
Vibrational properties of inclusion complexes: the case of indomethacin-cyclodextrin [PDF]
, 2006 Vibrational properties of inclusion complexes with cyclodextrins are studied by means of Raman spectroscopy and numerical simulation. In particular, Raman spectra of the non-steroidal, anti-inflammatory drug indomethacin undergo notable changes in the energy range between 1600 and 1700 cm$^{-1}$ when inclusion complexes with cyclodextrins are formed ...
arxiv +1 more source