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Chemogenomics for steroid hormone receptors (NR3) [PDF]

open access: yesCommunications Chemistry
The nine human NR3 nuclear receptors translate steroid hormone signals in transcriptomic responses and operate multiple highly important processes ranging from development over reproductive tissue function to inflammatory and metabolic homeostasis ...
Espen Schallmayer   +6 more
doaj   +2 more sources

Steroid hormone regulation of immunometabolism and inflammation [PDF]

open access: yesFrontiers in Immunology
The metabolism of immune cells adapts to support the energy demands for their activation, differentiation, and effector functions through a process known as metabolic reprogramming.
Ley Cody Smith   +4 more
doaj   +2 more sources

Effects of Copper on Steroid Hormone Secretion, Steroidogenic Enzyme Expression, and Transcriptomic Profiles in Yak Ovarian Granulosa Cells [PDF]

open access: yesVeterinary Sciences
Yak (Bos grunniens) is the main economic animal growing in the Qinghai–Tibet Plateau. Because of its poor growing environment, copper deficiency is common.
Yanbing Lou   +8 more
doaj   +2 more sources

Elevated RBP4 in Subclinical Ketosis Cows Inhibits Follicular Granulosa Cell Proliferation and Steroid Hormone Synthesis [PDF]

open access: yesAnimals
The mechanism by which subclinical ketosis (SCK) causes postpartum reproductive disorders in dairy cows remains unclear. In this study, cows within the day 14 to 21 postpartum period were categorized into the SCK group or the control group. Subsequently,
Chang Zhao   +6 more
doaj   +2 more sources

Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease

open access: yesMetabolites, 2021
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and may progress to cirrhosis or even hepatocellular carcinoma.
Meng Yang, Feng Ma, Min Guan
doaj   +1 more source

The interplay of sex steroid hormones and microRNAs in endometrial cancer: current understanding and future directions

open access: yesFrontiers in Endocrinology, 2023
IntroductionEndometrial cancer is a hormone-dependent malignancy, and sex steroid hormones play a crucial role in its pathogenesis. Recent studies have demonstrated that microRNAs (miRNAs) can regulate the expression of sex steroid hormone receptors and ...
Lovlesh Thakur, Sunil Thakur
doaj   +1 more source

The effect of etanercept therapy on adrenal steroid metabolism in juvenile idiopathic arthritis: a steroid metabolomics approach

open access: yesPediatric Rheumatology Online Journal, 2023
Objective To evaluate the impact of anti-tumor necrosis factor-alpha (TNFα: etanercept [Etanercept ®]) therapy on adrenal activity in juvenile idiopathic arthritis (JIA) .
Yonatan Butbul Aviel   +4 more
doaj   +1 more source

Ginsenosides improve reproductive capability of aged female Drosophila through mechanism dependent on ecdysteroid receptor (ECR) and steroid signaling pathway

open access: yesFrontiers in Endocrinology, 2022
Aging ovaries caused diminished fertility and depleted steroid hormone level. Ginsenosides, the active ingredient in ginseng, had estrogen-like hormonal effects.
Baoyu Fu   +10 more
doaj   +1 more source

Integrative Analysis of miRNA-mRNA in Ovarian Granulosa Cells Treated with Kisspeptin in Tan Sheep

open access: yesAnimals, 2022
Kisspeptin is a peptide hormone encoded by the kiss-1 gene that regulates animal reproduction. Our studies revealed that kisspeptin can regulate steroid hormone production and promote cell proliferation in ovarian granulosa cells of Tan sheep, but the ...
Tianshu Dai   +9 more
doaj   +1 more source

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