Corticosteroid Activation of Atlantic Sea Lamprey Corticoid Receptor: Allosteric Regulation by the N-terminal Domain [PDF]
Lampreys are jawless fish that evolved about 550 million years ago at the base of the vertebrate line. Modern lampreys contain a corticoid receptor (CR), the common ancestor of the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), which first appear in cartilaginous fish, such as sharks.
arxiv
Neurogenomic landscape associated with status‐dependent cooperative behaviour
Abstract The neurogenomic mechanisms mediating male–male reproductive cooperative behaviours remain unknown. We leveraged extensive transcriptomic and behavioural data on a neotropical bird species (Pipra filicauda) that performs cooperative courtship displays to understand these mechanisms.
Peri E. Bolton+6 more
wiley +1 more source
Summary Winter dormancy and bud break are crucial to the viability, adaptability and yield of fruit trees, but not all metabolic activities or regulatory factors involved in maintaining and breaking dormancy are known. Here, winter buds, spanning from natural dormancy to bud break, were collected from ‘Cabernet Sauvignon’ grapevines maintained outdoors
Li Chen+5 more
wiley +1 more source
Steroids for DOPed Applications: A Compiler for Automated Data-Oriented Programming [PDF]
The wide-spread adoption of system defenses such as the randomization of code, stack, and heap raises the bar for code-reuse attacks. Thus, attackers utilize a scripting engine in target programs like a web browser to prepare the code-reuse chain, e.g., relocate gadget addresses or perform a just-in-time gadget search.
arxiv
Light Quantity Impacts Early Response to Cold and Cold Acclimation in Young Leaves of Arabidopsis
ABSTRACT Plant reactions to stress vary with development stage and fitness. This study assessed the relationship between light and chilling stress in Arabidopsis acclimation. By analysing the transcriptome and proteome responses of expanding leaves subjected to varying light intensity and cold, 2251 and 2064 early response genes and proteins were ...
Markéta Luklová+14 more
wiley +1 more source
Occurence of active layer optical properties on some Lasing characteristics dye-doped Ch LC [PDF]
Effect of a planar texture quality and its thickness on lasing spectrums and thresholds in dye-doped cholesteric liquid crystal (CLC) of steroid type is explored. Transition from the qualitative planar texture to the poor texture quality is accompanied by change of characteristic mode structures and by shift of barycentre in the long-wave side and the ...
arxiv
Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy
ABSTRACT Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, and metabolic abnormalities.
Yao Shen+5 more
wiley +1 more source
Natural products targeting tumour angiogenesis
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu+2 more
wiley +1 more source
Aqueous solution interactions with sex hormone-binding globulin and estradiol: A theoretical investigation [PDF]
Sex hormone-binding globulin (SHBG) is a binding protein that regulates availability of steroids hormones in the plasma. Although best known as steroid carrier, studies have associated SHBG in modulating behavioral aspects related to sexual receptivity.
arxiv
Characterisation of neurogenic lipolytic responses in white adipose tissue ex vivo
Background and Purpose Dysfunction of the autonomic nervous system is associated with cardiovascular dysfunction, including metabolic syndrome and obesity. Understanding mechanisms of neurogenic control of white adipose tissue is key to understanding adipose physiology and pathophysiology, though there is limited research exploring this in adipose ...
Kayleigh E. Goddard, Samuel J. Fountain
wiley +1 more source