Results 81 to 90 of about 509,885 (240)
Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight [PDF]
arXivA meta-analysis of spaceflight data from both mouse and human flights reveals a striking overlap with Parkinson's disease (PD). Parallels include: changes in gait, loss of dopamine, sustained changes in the basal ganglia, loss of tyrosine hydroxylase in the substantia nigra, and systemic mitochondrial dysfunction.
arxiv
Clinical Endocrinology, Volume 102, Issue 5, Page 554-556, May 2025.
Olivia Buckingham‐Woodhouse +8 more
wiley +1 more source
Health Science Reports, Volume 8, Issue 4, April 2025.ABSTRACT Background and Objectives Atopic dermatitis (AD) is a common chronic inflammatory skin condition, affecting 15%–20% of children and up to 10% of adults. It has a significant impact on patients' quality of life and represents a considerable burden on healthcare systems. Management strategies aim to restore the skin barrier, reduce inflammation,
Bertrand Nassar +3 more
wiley +1 more source
Novel Nongenomic Signaling by Glucocorticoid May Involve Changes to Liver Membrane Order in Rainbow Trout [PDF]
arXiv, 2017 Stress-induced glucocorticoid elevation is a highly conserved response among vertebrates. This facilitates stress adaptation and the mode of action involves activation of the intracellular glucocorticoid receptor leading to the modulation of target gene expression. However, this genomic effect is slow acting and, therefore, a role for glucocorticoid in
arxiv
Duplicate entries in the Protein Data Bank: how to detect and handle them
Acta Crystallographica Section D, Volume 81, Issue 4, Page 170-180, April 2025.A global analysis of protein crystal structures in the Protein Data Bank (PDB) reveals many pairs with (nearly) identical main‐chain coordinates. Such cases are identified and analyzed, leading to a proposal about how the PDB could ameliorate this problem.A global analysis of protein crystal structures in the Protein Data Bank (PDB) using a newly ...
Alexander Wlodawer +8 more
wiley +1 more source
BERTQA -- Attention on Steroids [PDF]
arXiv, 2019 In this work, we extend the Bidirectional Encoder Representations from Transformers (BERT) with an emphasis on directed coattention to obtain an improved F1 performance on the SQUAD2.0 dataset. The Transformer architecture on which BERT is based places hierarchical global attention on the concatenation of the context and query.
arxiv
Journal of Neuroendocrinology, Volume 37, Issue 4, April 2025.Abstract We recently showed that Crh‐Crhr1 signalling is essential for acute stress‐related locomotor activity in zebrafish larvae. However, the possibility that Crhr1 activation may also initiate the acute metabolic demands for stress coping was unexplored.
Zachary Shvartsburd +1 more
wiley +1 more source
Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene. [PDF]
, 1986 Yasuhiro Higashi +4 more
openalex +1 more source
Profile Likelihoods on ML-Steroids [PDF]
arXivProfile likelihoods, for instance, describing global SMEFT analyses at the LHC are numerically expensive to construct and evaluate. Especially profiled likelihoods are notoriously unstable and noisy. We show how modern numerical tools, similar to neural importance sampling, lead to a huge numerical improvement and allow us to evaluate the complete ...
arxiv