Results 241 to 250 of about 621,799 (362)

Evaluation of Biological Activity of Two Steroid Derivatives on Glucose Levels Using a Diabetic Model

open access: diamond, 2020
Figueroa‐Valverde Lauro   +99 more
openalex   +1 more source

A Supramolecular Nanoscavengers: Based “Cargo‐Exchange” Breaking Cholesterol Metabolic Dysregulation for Glioblastoma Therapy

open access: yesAdvanced Science, EarlyView.
Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM). In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small‐molecule cholesterol and β‐cyclodextrin (β‐CD).
Zonghua Tian   +7 more
wiley   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

open access: yesAdvanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao   +8 more
wiley   +1 more source

A systematic review of steroid use in peripheral nerve pathologies and treatment. [PDF]

open access: yesFront Neurol
Couch B   +6 more
europepmc   +1 more source

Assessment of hepatic cytochrome P450 3A activity using steroid metabolic markers in patients with renal impairment

open access: diamond, 2018
Andrew Hyoungjin Kim   +5 more
openalex   +2 more sources

Stereoselective Ferrier‐Type O‐Glycosylation Enabled by Difluoromethylated Glycal Donors

open access: yesAdvanced Science, EarlyView.
A fluorine‐mediated stereoselective Ferrier‐type glycosylation is reported. Glycals are pre‐decorated with photo‐2‐difluoroalkylation and reacted with diverse acceptors to obtain exclusively α‐selective Ferrier rearrangement products. Abstract The effective construction of structurally homogeneous glycosides is requisite in oligosaccharide assembly and
You Zou   +5 more
wiley   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

open access: yesAdvanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li   +7 more
wiley   +1 more source

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