Results 51 to 60 of about 429,473 (311)

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis [PDF]

, 2014
T helper 2 (Th2) cells regulate helminth infections, allergic disorders, tumor immunity, and pregnancy by secreting various cytokines. It is likely that there are undiscovered Th2 signaling molecules.
Xiuwei Zhang, Sarah A. Teichmann, Zhang, Xiuwei, Dingler, Felix A., Felix A. Dingler, Teichmann, Sarah A., Valentina Proserpio, Berthold Göttgens, Dingler, Felix A, Kolodziejczyk, Aleksandra A, Teichmann, Sarah A, Proserpio, V, Taylor, Angela E., Hebenstreit, Daniel, Taylor, Angela E; id_orcid, Proserpio, Valentina, Haim-Vilmovsky, Liora, McKenzie, Andrew N J, Liora Haim-Vilmovsky, Göttgens, Berthold, Andrew N.J. McKenzie, Arlt, Wiebke, Angela E. Taylor, McKenzie, Andrew N.J., Daniel Hebenstreit, Kolodziejczyk, Aleksandra A., Aleksandra A. Kolodziejczyk, Wiebke Arlt, Victoria Moignard, Moignard, Victoria, McKenzie, Andrew N. J., Bidesh Mahata, Mahata, Bidesh   +32 more
core   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Microbiota modulates the steroid response to acute immune stress in male mice

Frontiers in Immunology
Microbiota plays a role in shaping the HPA-axis response to psychological stressors. To examine the role of microbiota in response to acute immune stressor, we stimulated the adaptive immune system by anti-CD3 antibody injection and investigated the ...
Karla Vagnerová, Taťána Gazárková, Martin Vodička, Peter Ergang, Petra Klusoňová, Tomáš Hudcovic, Dagmar Šrůtková, Petra Petr Hermanová, Lucie Nováková, Jiří Pácha, Jiří Pácha   +10 more
doaj   +1 more source

Efficacy of corticosteroid solution administration via Mygind's position for the management of chronic rhinosinusitis with nasal polyps

Laryngoscope Investigative Otolaryngology, 2020
Objective To investigate whether direct steroid application via Mygind's position improved objective and subjective measures of chronic rhinosinusitis with nasal polyposis (CRSwNP).
Ashwini M. Tilak, Spencer C. Payne
doaj   +1 more source

Glucocorticoid receptor activation by long acting steroids and its modification by inflammation [PDF]

, 2007
s: Glucocorticoids have an effective anti-inflammatory, anti-proliferative and immunomodulatory activity. Therefore this class of drugs is used worldwide for the treatment of inflammatory diseases and to prevent rejection following organ transplantation.
Yang, Jing-Qing
core   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Steroids [PDF]

, 2012
Steroids - From Physiology to Clinical Medicine covers contemporary basic science on steroids research, along with steroids practical application in clinical medicine.

core   +3 more sources

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Short and Long-Term Outcomes of Diabetes Mellitus in Patients with Autoimmune Pancreatitis after Steroid Therapy

Gut and Liver, 2012
Background/AimsAutoimmune pancreatitis (AIP) is frequently associated with diabetes mellitus (DM). This study evaluated the effect of steroid therapy on the course of DM in AIP.Methods : Glucose tolerance was examined in 69 patients with AIP.
doaj   +1 more source