Results 51 to 60 of about 438,779 (309)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Bismuth(III) Reagents in Steroid and Terpene Chemistry
Molecules, 2011 Steroid and terpene chemistry still have a great impact on medicinal chemistry. Therefore, the development of new reactions or “greener” processes in this field is a contemporaneous issue.
Jorge A. R. Salvador +2 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Dermatology ReportsDear Editor, Systemic glucocorticoids remain a cornerstone of therapy in immunobullous diseases. Yet little is known about glucocorticoid induced osteoporosis (GIOP) in patients with immunobullous diseases. We performed a retrospective review of medical
MeiQi May Liau, Nisha Suyien Chandran
doaj +1 more source
Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]
, 2010 Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
H-1 NMR determination of adulteration of anabolic steroids in seized drugs
, 2018 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Counterfeiting and adulteration of pharmaceuticals is a prevalent problem worldwide and represents a major health risk to the population, with anabolic steroids being one of the main ...
Pezza, Leonardo [UNESP] +9 more
core +1 more source
Distinction between epimeric 3-hydroxi steroids by mass analyzed ion kinetic energy spectrometry [PDF]
, 1982 Gonzalez JE, Grützmacher H-F. Distinction between epimeric 3-hydroxi steroids by mass analyzed ion kinetic energy spectrometry. Organic Mass Spectrometry.
Gonzalez, Jaime Espinosa +1 more
core +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
, 2019 Hair steroids and their ratios are believed to be reliable biomarkers reflecting the long-term exposure of circulating steroids. Hereinto, two underlying assumptions are that hair biomarkers have consistency with traditional biomarkers in saliva or urine,
Wang, Weiwen +5 more
core +1 more source