Results 91 to 100 of about 2,491,702 (230)

Stevens-Johnson Syndrome and Erythema Multiforme Induced by Imiquimod 5% Cream

Dermatology Practical & Conceptual
Introduction: Topical imiquimod is a safe and effective treatment for actinic keratoses, superficial basal cell carcinomas and anogenital warts. The treatment is commonly associated with local inflammatory reactions, while systemic side effects are rare
Ilaria Salvi, Ilaria Trave, Riccardo Castelli, Aurora Parodi, Emanuele Cozzani   +4 more
doaj   +1 more source

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2183-2192, July 2026.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Phenytoin-induced Stevens–Johnson syndrome with myocarditis: a rare case report

, 2017
Ashwin Kodliwadmath Department of Medicine, Belgaum Institute of Medical Sciences, Belgaum, India Abstract: Stevens–Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction caused by excessive necrosis and detachment of the ...
Kodliwadmath A
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Stevens - Johnson Syndrome Induced by Sorafenib for Hepatocellular Carcinoma [PDF]

, 2016
Background: Sorafenib is a new therapeutic agent being used in hepatocellular carcinoma, renal cell carcinoma and malignant melanoma. The most frequently seen cutaneous side effects due to sorafenib are erythema, exfoliative dermatitis, acne vulgaris and
Chakiri R, Meziane M, Douhi Z, Mernissi FZ   +3 more
core   +1 more source

Data_Sheet_1_Case report: Development of vanishing bile duct syndrome in Stevens-Johnson syndrome complicated by hemophagocytic lymphohistiocytosis.pdf

, 2022
BackgroundVanishing bile duct syndrome is a rare drug-induced disease characterized by cholestasis and ensuing ductopenia. Dermatological manifestations of drug hypersensitivity such as Stevens-Johnson syndrome and toxic epidermal necrolysis may also ...
Chia-Yu Chu (320225), Wan-Chen Lin (658261), Tyng-Shiuan Hsieh (13999875)   +2 more
core   +1 more source

HLA genotype testing for carbamazepine, oxcarbazepine and eslicarbazepine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 1957-1976, July 2026.
Carbamazepine is licensed in the United Kingdom for the treatment of epilepsy, bipolar disorder and trigeminal neuralgia. The related compounds oxcarbazepine and eslicarbazepine are licensed for the treatment of epilepsy. These drugs can cause immune‐mediated hypersensitivity reactions, which typically affect the skin, and can be of variable severity ...
Lucy Galloway, Cinzia Dello Russo, Nicholas Bass, Elvira Bramon, Helen Cross, Natalie Curley, Sarah Curran, Helen Davies, Jana De Villiers, William Evans, Bernhard Frank, Alice Groves, Judith Hayward, Jon Higham, Dyfrig A. Hughes, Shwe Sin Kyaw, Anthony G. Marson, Ailsa McLellan, Seth Mensah, Francis O'Neill, Jane Sargison, Sanjay M. Sisodiya, Jill Swan, Joanna M. Zakrewska, Munir Pirmohamed   +24 more
wiley   +1 more source

Stevens-Johnson induced by imiquimod 5% cream: a case report

Dermatology Reports
Imiquimod 5% cream is an approved treatment for actinic keratoses, superficial basal cell carcinomas and anogenital warts. Severe systemic side effects associated to imiquimod 5% cream are rare, although few cases of erythema multiforme and Stevens ...
Ilaria Trave, Ilaria Salvi, Claudia Micalizzi, Riccardo Castelli, Aurora Parodi, Emanuele Cozzani   +5 more
doaj   +1 more source

Phenobarbital‐Induced Toxic Epidermal Necrolysis: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Adverse drug reactions (ADRs) can lead to severe consequences and increased morbidity and mortality rates. Phenobarbital is one of the most common anti‐epileptic drugs that has numerous adverse drug reactions, including toxic epidermal necrolysis. The event is rare and a medical emergency.
Biniyam Tedla Mamo, Solomon Getnet Meshesha, Zelalem Aysheshim Andualem, Kisi Chemeda Gutema, Abenezer Abrham Anito, Mehiret Maru Haile, Hilina Worku Jembere, Asnakech Alemu, Teshita Shute   +8 more
wiley   +1 more source

Stevens-Johnson syndrome: case report

, 2013
Stevens-Johnson-ov sindrom je rijetkak i po život opasna akutna alergijska reakcija koja utječe na kožu i sluznicu. Prikazali smo kliničku sliku, vrjednovanje i liječenje 9-godišnje djevojčice sa Stevens-Johnson-ovim sindromom, koji se pojavio nakon ...
Muci, Manisa, Kuneshka, Numila
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Cutaneous Adverse Drug Reactions Associated With BRAF and MEK Inhibitors: A Real‐World Analysis of WHO Pharmacovigilance Data

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 274-285, July 2026.
BRAF inhibitors and MEK inhibitors (MEKi) have reshaped the treatment of BRAFV600‐mutant malignancies; however, cutaneous adverse drug reactions (ADRs) remain a frequent and clinically impactful toxicity. Although clinical trials provide insight into their safety profiles, real‐world data on dermatologic ADRs are limited.
Natalia Sauer, Piotr Giedziun, Jacek Calik, Anna Wiela‐Hojeńska   +3 more
wiley   +1 more source