Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen +3 more
wiley +1 more source
Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two cases
Stevens-Johnson syndrome and drug reaction with eosinophilia and systemic symptoms are severe cutaneous adverse reactions to drugs that are generally considered distinct entities.
Laura D Chin +3 more
doaj +2 more sources
Incidence of components of metabolic syndrome in the metabolically healthy obese over 9 years follow-up: the Atherosclerosis Risk In Communities study. [PDF]
BackgroundSome obese adults are not afflicted by the metabolic abnormalities often associated with obesity (the 'metabolically healthy obese' (MHO)); however, they may be at increased risk of developing cardiometabolic abnormalities in the future. Little
Bradshaw, PT +4 more
core +2 more sources
Mycoplasma pneumoniae‐Induced Rash and Mucositis: Clinicopathologic Characterization of 11 Cases
ABSTRACT Background Mycoplasma pneumoniae ‐induced rash and mucositis (MIRM) is a mucocutaneous eruption affecting children and young adults with respiratory tract or clinically occult infection by M. pneumoniae . Mucosal involvement is often robust and may raise concern for Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Histopathologic
Margaret Lang Houser +5 more
wiley +1 more source
Tramadol-induced Stevens-Johnson syndrome [PDF]
Stevens-Johnson syndrome and toxic epidermal necrolysis are acute and severe life-threatening allergic reactions. Their incidences in Thailand may be underestimated due to a lacking of reports.
Limtanyakul, Piyakan +3 more
core +1 more source
Integrating the Microbiome Into Infection Ecology and Evolution in Wild Animals
ABSTRACT Parasites are a ubiquitous force in nature threatening wildlife populations and ecosystems. Interactions between hosts and their parasites are impacted by host‐associated microbiomes, which are essential for host development, physiology and immunity.
Jingdi Li +5 more
wiley +1 more source
Prompt versus delayed amniotic membrane application in a patient with acute Stevens-Johnson syndrome
Jessica B Ciralsky, Kimberly C SippelDepartment of Ophthalmology, Weill Cornell Medical College, New York, NY, USABackground: Stevens-Johnson syndrome is often associated with blinding ocular surface cicatricial sequelae.
Ciralsky JB, Sippel KC
doaj
Purpose: To review the possible aetiological factors, ocular complications and their management in patients of Stevens-Johnson syndrome with ocular involvement, seen at a tertiary eye care centre.
Kompella Viswanadh +5 more
doaj
Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs [PDF]
Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who ...
Lawrence Cohen +3 more
core +1 more source
Levofloxacin and Ibuprofen Leading to Steven Johnson Syndrome: A Dermatological Emergency
Stevens-Johnson syndrome is a rare, serious disorder of your skin and mucous membranes. It's usually a reaction to a medication or an infection. Often, it begins with flu-like symptoms, followed by a painful red or purplish rash that spreads and blisters.
Muhammad Raheel Zafar et al.,
doaj

