Diagnosis and management of reactive infectious mucocutaneous eruption
Abstract Medicine's clinical understanding of reactive infectious mucocutaneous eruption (RIME) has evolved over time. It was previously described as Mycoplasma pneumoniae‐induced rash and mucositis (MIRM), and before that as a variant of Stevens‐Johnson Syndrome/Toxic Epidermal Necrolysis. Here, we summarize the current understanding of best practices
Nicole Damari+2 more
wiley +1 more source
Stevens-Johnson Syndrome while on lamotrigine and NSAID:A case report
Stevens-Johnson syndrome is a severe immune-mediated cutaneous reaction occurring due to exposure to certain drugs. Lamotrigine is an FDA approved drug used in the treatment of bipolar depression. When it is given concomitantly with sodium valproate, the
Madhavi Bhat+6 more
doaj +1 more source
Amoxycillin and clavulanic acid induced Stevens-Johnson syndrome: a case report [PDF]
Stevens-Johnson syndrome (SJS) is an immune complex mediated hypersensitivity complex that typically involves the skin and the mucous membranes. Various etiologic factors (e.g., infection, drugs and malignancies) have been implicated as causes of Stevens-
Krishnegowda, Neha+3 more
core +2 more sources
A Pilot Trial of a Novel Skin Substitute on Chronic and Recurrent Epidermolysis Bullosa Wounds
ABSTRACT Background Epidermolysis bullosa (EB) is a rare genetic skin fragility disease. The Recessive Dystrophic subtype (RDEB) causes severe manifestations and leads to early mortality. Two topical therapies have recently been approved, but they are not curative.
Yuri Ikeda+11 more
wiley +1 more source
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP2C9 and HLA-B Genotype and Phenytoin Dosing [PDF]
Phenytoin is a widely used antiepileptic drug with a narrow therapeutic index and large inter-patient variability partly due to genetic variations in CYP2C9.
Callaghan, J. Thomas+7 more
core +3 more sources
Prevalence of Esophageal Webs in Patients Undergoing Direct Laryngoscopy
PES webs may be more common than what is traditionally cited in the literature. The prevalence of PES webs in this retrospective cohort study was found to be 34%. Webs may be more likely in patients with a history of irradiation to the head and neck, and only one‐third of patients with a PES web in our cohort had dysphagia symptoms.
Zao M. Yang+5 more
wiley +1 more source
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin+8 more
wiley +1 more source
Skin reactions probably attributed to the use of phenytoin and vancomycin [PDF]
Cutaneous reactions are the most common adverse events attributed to medications. Stevens-Johnson syndrome or erythema multiforme is a severe and acute reaction determined by medications, especially aspirin, phenytoin, and vancomycin.
Carla Tozato+2 more
doaj
ACECLOFENAC-INDUCED STEVENS-JOHNSON SYNDROME AFTER ONE SINGLE DOSE: A MAIDEN CASE REPORT [PDF]
Drugs are known to cause various adverse drug reactions involving major organ systems. Skin-related adverse reactions are very common and range from a simple rash to life-threatening condition like Stevens-Johnson syndrome.
Agarwal, Saurabh+2 more
core +1 more source
Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy
Abstract Background Progressive supranuclear palsy (PSP) is a neurodegenerative disease driven by 4‐repeat τ pathology, which is thought to propagate across interconnected neurons. Objectives We hypothesized that interconnected brain regions exhibit correlated atrophy, and that atrophy propagates network‐like from fast‐declining epicenters to connected
Carla Palleis+183 more
wiley +1 more source